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The effect of anisodamine on lipoprotein metabolism in the liver and hepatocyte membrane phospholipids was studied on a model of hemorrhagic shock. Preliminary injection of anisodamine raised the content of very low-density lipoproteins in blood of the central vessels and intensified the breakdown
OBJECTIVE
To investigate the possible role of IkappaB kinase-beta (IKK-beta), the pathogenesis of hepatic injury induced by resuscitation of hemorrhagic shock and endotoxin, and to evaluate the preventive effect of anisodamine (654-2).
METHODS
Twenty-seven rabbits were randomly divided into the
Anisodamine , an alkaloid extracted from Anisodus tanguticus , is widely used in China in the treatment of septic shock, but its mechanism of action is unknown. We studied its antishock action in cats in a well controlled model of hemorrhagic shock. A bolus dose of 1 mg/kg was given intravenously 20
Experimental study had been conducted on 18 healthy adult mongral dogs of both sex, weighting from 7.5-11 kg, randomly divided into four groups. Experimental models of acute hemorrhagic necrotizing pancreatitis (AHNP) were established by retrograde injecting 1 ml/kg of sodium taurocholate directly
OBJECTIVE
To compare the diagnostic capabilities between capsule endoscopy (CE) and multislice CT (MSCT) enterography in combination with MSCT angiography for assessment of obscure gastrointestinal bleeding (OGIB).
METHODS
A total of 127 patients with OGIB were looked at in this study. 82 patients
Acute disseminated intravascular coagulation (DIC) is a life-threatening condition that may be encountered in many situations, especially in cases of shock with uncontrollable hemorrhage. Anisodamine, an alkaloid extracted from a Chinese herb, is well known for its dramatic therapeutic effect on
Anisodamine at dose of iv 10 and 20 mg/kg prolonged plasma prothrombin time, bleeding time and coagulation time, and showed positive reaction of plasma protamine paracoagulation test in conscious rabbits. The drug prolonged the thrombin time and reduced the contend of plasma fibrin. Anisodamine
Anisodamine was used as an antishock (chiefly septic) drug beginning in the early 1960s in China. Its underlining mechanism was believed to be due to its vasodilative action. But in normal animals it only produces slight vasodilation. Our work during the recent 15 years proved that anisodamine is
BACKGROUND
Infusion phlebitis is the most common side effect of clinical intravenous drug therapy and several clinical studies have demonstrated that anisodamine can effectively prevent the occurrence of infusion phlebitis. This study was designed to investigate effects of anisodamine on the
To evaluate efficacy, safety and feasibility of targeted intracoronary injection using pro-urokinase combined with anisodamine (TCA) versus thrombus aspiration (TA) in ST-elevation myocardial infarction (STEMI) patients with high thrombus loads.The best The antishock effect of anisodamine (654-2) was observed in different kinds of experimental shock in groups of rabbits--due to late hemorrhage, superior mesenteric artery occlusion, and septic shock from peritonitis. The drug 654-2 significantly alleviated the progress of shock and increased the
Anisodamine, an alkaloid originally extracted from the Chinese herb Anisodus tanguticus, has been reported to possess beneficial actions in septic, superior mesenteric artery occlusion, and hemorrhagic shock. We have investigated its actions in traumatic shock in rats. Anisodamine (2.5 mg/kg)