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asthenozoospermia/glutathione
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Effect of lipoic acid supplementation on gene expression and activity of glutathione S-transferase enzyme in infertile men.
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Oxidative stress has become the focus of interest as a potential cause of male infertility. We evaluate effects of lipoic acid (LA) supplementation on glutathione S-transferase (GST) expression. This randomized, triple-blind, placebo-controlled clinical trial was conducted on 44 infertile males with
Oxidative stress markers in seminal plasma of idiopathic infertile men may be associated with glutathione S-transferase M1 and T1 null genotypes
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This study aimed to investigate the association between glutathione S-transferase (GST) M1 and T1 null genotypes and thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) and nitric oxide (NO) levels in male infertility. For this purpose, semen samples were collected from
The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men.
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This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be
A proteomic analysis on human sperm tail: comparison between normozoospermia and asthenozoospermia.
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OBJECTIVE
Asthenozoospermia is a common cause of human male infertility characterized by reduced sperm motility. The molecular mechanism that impairs sperm motility is not fully understood. This study proposed to identify novel biomarkers by focusing on sperm tail proteomic analysis of
Dietary supplementation with a novel L-carnitine multi-micronutrient in idiopathic male subfertility involving oligo-, astheno-, teratozoospermia: a randomized clinical study.
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Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels.
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OBJECTIVE
To clarify the role of carnitine supplementation in idiopathic asthenozoospermia and to look for a rationale for its use in asthenozoospermic patients.
METHODS
Blind clinical study.
METHODS
Academic.
METHODS
Thirty asthenozoospermic patients divided in two groups according to phospholipid
Glutathione peroxidase activity in seminal plasma and its relationship to classical sperm parameters and in vitro fertilization-intracytoplasmic sperm injection outcome.
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OBJECTIVE
To relate the glutathione peroxidase (GPX) activity level in human seminal plasma with standard semen parameters and spermatozoa fertilization potential in terms of fertilization and pregnancy rates in an IVF program.
METHODS
Prospective study.
METHODS
Human Reproduction Unit at Cruces
Oxygen free radicals and mitochondrial signaling in oligospermia and asthenospermia.
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The aim of this study was to investigate the roles of oxygen free radicals and mitochondrial signaling in semen disorders, in particular, how this induces low concentrations and reduced motility of sperm. Ejaculate samples were obtained from 120 young adult males (mean age, 28.7±5.3 years) with
[Antioxidating and energy metabolism improving effects of Qiangjing Decoction on oligospermia and asthenospermia: An experimental study].
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OBJECTIVE
To explore the mechanisms of Qianjing Decoction in the treatment of oligoasthenospermia (OAS).
METHODS
We randomly divided 100 SPF male rats into five groups of equal number: normal, model, Huangjingzanyu, levocarnitine, and Qiangjing. OAS models were established in the animals followed by
Characterizing semen abnormality male infertility using non-targeted blood plasma metabolomics.
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Semen abnormality (SA) male infertility has become a worldwide reproductive health problem. The invasive tests (e.g., testicular biopsy) and labor-intensive methods of semen collection severely inhibit diagnosis of male infertility. In addition, the pathogenesis and biological interpretation of male
To Evaluate the Efficacy of Combination Antioxidant Therapy on Oxidative Stress Parameters in Seminal Plasma in the Male Infertility.
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BACKGROUND
Infertility is defined as inability to conceive after 1 year of unprotected intercourse and it affects 7% of male population and 8-10% of couples. According to estimates WHO, 13-19 million couples in India are infertile. Oxidative stress is the causative factor in 25% of infertile
The Associations between Infertility and Antioxidants, Proinflammatory Cytokines, and Chemokines.
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The aim of the study was to evaluate the parameters of oxidative stress and antioxidant defense in relation to the levels of proinflammatory cytokines and chemokines in patients diagnosed with oligozoospermia and asthenozoospermia. Based on the basic parameters of the spermogram, the examined group
Indications of the mechanisms involved in improved sperm parameters by zinc therapy.
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OBJECTIVE
To determine possible indications of the mechanisms involved in improved sperm parameters by zinc therapy in asthenozoospermic men.
METHODS
Forty-five men with asthenozoospermia (>or=40% immotile sperm) were randomized into four therapy groups: zinc only: n = 11; zinc + vitamin E: n = 12
Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate.
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OBJECTIVE
Infertility is an important medical and social problem that has an impact on well-being. A significant development in the last 10 years in the study of human infertility has been the discovery that oxidative sperm DNA damage has a critical role in the etiology of poor semen quality and
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