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The Effect of Human Urinary Kallikrein on Corticospinal Tract Injury in Acute Ischemia Stroke Patients

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The investigators collected 80 patients with acute cerebral infarction from July 2007 to March 2019 in the Department of Neurology, Second Hospital of Hebei Medical University. They were randomly divided into Kallikrein+standard treatment group and standard treatment group. And both groups were

Spectralis HRA+OCT Imaging of the Retina With Autofluorescence in Sickle Cell Disease

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About 10% of African Americans have an abnormal hemoglobin gene. About 8% of African Americans are heterozygous for Hb S. In the United States, sickle cell anemia primarily occurs in the black population, with approximately 0.2% of African American children afflicted by this disease. The prevalence

NHLBI/NICHD Collaborative Studies of Asthma in Pregnancy

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BACKGROUND: Asthma is one of the most common illnesses that complicates pregnancy. Asthma complicates at least 4 percent of all pregnancies; however, because at least 10 percent of the population appears to have nonspecific airway hyper-responsiveness, the true prevalence may be much higher. Asthma

RLF-100 (Aviptadil) Intermediate Population Expanded Access Protocol (SAMICARE)

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5. INTRODUCTION 5.1 Executive Summary RLF-100 (aviptadil) is a synthetic form of Vasoactive Intestinal Polypeptide (VIP), a ubiquitous, naturally synthesized human peptide with extensively documented anti-inflammatory, anti-cytokine cascade properties. It has been granted FDA Fast Track Designation
A. Specific Aims/Objectives Specific Aim 1: To determine regional compliance and distribution of ventilation in a cohort of children requiring mechanical ventilation. Hypothesis - Abnormal distribution of ventilation will be discovered in all patients. Specific Aim 2: To determine changes in

Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial

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Introduction Background and objectives. In early 2020 novel Coronavirus disease (COVID-19) begun to spread from Asia to Europe and beyond forcing WHO to declare global pandemic. Infected patients shed the virus for a median of 20 days. Up to 10% of COVID-19 infected patients develop a severe form of

Progesterone Treatment of Blunt Traumatic Brain Injury

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Title: Progesterone Treatment of Blunt Traumatic Brain Injury Principal Investigator(s): Arthur Kellermann, M.D., M.P.H. Institution: Emory University Biostatistician: Vicki Hertzberg, Ph.D. Institution: Emory University Project phase or primary methodology: Phase II pilot, double blind, 4:1
Background of the Project including Preliminary Observations Hypertensive disorders of pregnancy, including preeclampsia, complicate up to 10% of pregnancies worldwide, constituting one of the greatest causes of fetal growth restriction, preterm birth, low birth weight, perinatal mortality, and
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