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brevifoliol/taxus brevifolia
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Seasonal and tissue variation in taxane concentrations of Taxus brevifolia.
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Analysis of seven taxanes: taxol, baccatin III, 10-deacetyltaxol, 10-deacetylbaccatin III, 7-xylosyl-10-deacetyltaxol, cephalomannine and brevifoliol in extracts from bark and foliage of pacific yew (Taxus brevifolia) showed a gradient of decreasing concentration from stem base to branch tip. This
Isolation and structure elucidation of new taxoids from Taxus brevifolia.
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An investigation of Taxus brevifolia extracts afforded two taxoids characterized by the A-nortaxol ring system. These were identified as 7,13-dideacetyl-9,10- debenzoyltaxchinin C [1] and 9-deacetyl-9-benzoyl-10-debenzoylbrevifoliol [4]. Structures were elucidated by spectroscopic methods, and in
A new large-scale process for taxol and related taxanes from Taxus brevifolia.
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OBJECTIVE
In view of the demonstrated antitumor activity of taxol, ready availability of the drug is important. The current isolation methods starting from the bark of Taxus brevifolia involve multiple manipulations, leading to only taxol and in a yield of 0.01%. A new process consisting of a single
Screening of the needles of different yew species and cultivars for paclitaxel and related taxoids.
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The needles of several yew species and cultivars were analysed by high-pressure liquid chromatography for paclitaxel, 10-deacetylpaclitaxel, cephalomannine, baccatin III, 10-deacetylbaccatin III and brevifoliol. About 750 samples were collected from five different locations in the Netherlands and
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