bronchopulmonary dysplasia/muntah

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Role of Montelukast in Modulation of Response to Sepsis in Preterm Infants

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Since inflammatory mediators play a crucial role in the pathophysiology of sepsis so anti-inflammatory treatment, Montelukast, could be a beneficial therapy. The investigators will conduct this pilot, open-labeled, randomized controlled intervention trial on 40 newborns admitted to NICU. The study

Transgastrostomal Endoscopies

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Pediatric esophagogastroduodenoscopies (EGD) are commonly used for diagnosis and treatment of various GI conditions. Appropriate sedation or anesthesia and analgesia is critical for enhancing the effectiveness and feasibility of EGD. General anesthesia or deep sedation are commonly used for this

Early Routine vs. Selective Human Milk Fortification in Extremely Preterm Infants

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II. BACKGROUND Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease affecting >10% of extremely preterm infants with a mortality of up to 50%. The pathophysiology is poorly understood, but intestinal immaturity, microbial colonization, hypoxic ischemia, and diet have all been

Duodenal Feeds in Very Low Birth Weight Infants

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The primary outcome of this study is the safety and feasibility of duodenal feeds in very low birth weight infants. The secondary outcomes are various measures related to growth, respiratory support, comorbidities, and hospitalization. Eligibility of infants admitted to the Johns Hopkins All

Enteral Nutrition Tolerance And REspiratory Support (ENTARES)

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BACKGROUND: Respiratory distress syndrome (RDS) is a common condition in premature infants and one of the major cause of neonatal mortality. For many years, preterm infants with RDS have been treated with mechanical ventilation increasing risks of acute lung injury and long-term morbidity, as

Work of Breathing During Non-invasive Ventilation in Premature Neonates

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Background/Rationale: Historically, respiratory insufficiency and respiratory failure have been frequent sources of morbidity and mortality in premature neonates. Intubation for invasive mechanical ventilation has been a life-saving therapy for many of these patients, but is not without risks. These

The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease

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STUDY DESIGN AND METHODS Overview: This pilot randomized control trial (RCT) will enroll 92 children from 6 months to 6 years of age that have chronic lung disease (CLD) such as bronchopulmonary dysplasia during two pulmonary illness seasons. If the minimum number of patients (n=92) in Season 1 is

NiPPV in the Treatment of Acute Asthma Exacerbations

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This study is a prospective and randomized clinical trial to investigate the utility of BiPAP therapy for the pediatric patient in an acute moderate to severe asthma exacerbation. The study will be conducted in the pediatric emergency department at Arkansas Children's Hospital. Patients between 2-17

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