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castanospermine/atrofi
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The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats.
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To better characterize and compare the toxicity of and lesions produced by locoweed (Astragalus mollissimus) with those of swainsonine and a related glycoside inhibitor, castanospermine, 55 Sprague-Dawley rats were randomly divided into 11 groups of five animals each. The first eight groups were
Carbohydrates play a role in neurite outgrowth in vivo during development and regeneration.
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We have used the alpha-glucosidase inhibitor, castanospermine, to investigate the possible involvement of N-linked glycosylation in the process of neurite outgrowth both during the development and regeneration of sympathetic nerve fibres into the iris of the rat. The effects on nerve growth were
The toxicity of Castanospermum australe seeds for cattle.
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Two calves given a mean of 16.1 g and 16.4 g ripe Castanospermum australe seeds/kg body weight daily for 13 and 16 days respectively developed haemorrhagic gastroenteritis. The first calf died. The second calf had mild myocardial degeneration and necrosis and mild nephrosis at necropsy. Two calves
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