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Population pharmacokinetics of rhTNFR-Fc in healthy Chinese volunteers and in Chinese patients with Ankylosing spondylitis.
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OBJECTIVE
To investigate the population pharmacokinetics of recombinant human tumor necrosis factor receptor-Fc fusion protein (rhTNFR-Fc) administered via subcutaneous (SC) injection in healthy Chinese volunteers and in Chinese patients with ankylosing spondylitis (AS).
METHODS
Thirty-two healthy
[Apoptosis induction of traditional Chinese herb pianzihuang ([Chinese characters: see text]) in human osteosarcoma U-20S cells].
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OBJECTIVE
To study the effect of apoptosis induction of pianzihuang in human osteosarcoma U-20S cells.
METHODS
Sixth SD rats were randomly divided into group A (8 rats) and group B (8 rats) in the study. Among them, 8 rats (group A) were treated with PBS and 8 rats (group B) treated with
Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease.
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OBJECTIVE
Tumor necrosis factor alpha (TNF-alpha) may play a central role in the development of Graves' disease (GD). The aim of this study was to investigate the association of TNF-alpha polymorphisms with GD in Chinese population.
METHODS
Genomic DNA was extracted from peripheral blood lymphocyte
[Peritubular capillary injury in Chinese herb guan-mu-tong-induced acute tubular necrosis].
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OBJECTIVE
To explore the role and mechanisms of peritubular capillary (PTC) injury in the progression of Chinese Herb guan-mu-tong (GMT, aristolochiae manshuriensis kom) induced acute tubular necrosis (GMT-ATN).
METHODS
Renal biopsy tissue from 4 cases of GMT-ATN and 5 cases of antibiotic induced
Acculturative stress and inflammation among Chinese immigrant women.
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OBJECTIVE
Among Chinese immigrant populations, increasing duration of US residence is associated with elevated risk for various chronic diseases. Although life-style changes after migration have been extensively studied in immigrant populations, the psychosocial impact of acculturative stress on
Cytokine gene polymorphisms in Chinese patients with psoriasis.
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BACKGROUND
Previous studies have shown that cytokine gene polymorphisms may confer susceptibility to psoriasis.
OBJECTIVE
To determine whether genetic polymorphisms of the cytokine genes might influence the development of psoriasis in Chinese patients in Taiwan.
METHODS
DNA samples were obtained
Wound healing in normal and diabetic Chinese hamsters.
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Wound healing was examined in normal and diabetic, non ketotic Chinese hamsters by morphological and morphometric methods. Dermal, perforating wounds were made in the ears of the hamsters and the response to injury was evaluated in tissue biopsies. The response in normal hamsters was characterized
Food bolus intestinal obstruction in a Chinese population.
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BACKGROUND
The aim of the present study was to review the authors' experience of the diagnosis and management of food bolus obstruction in a Chinese population.
METHODS
During the period 1990-96, 31 patients were treated for food bolus obstruction. The records of these patients were retrospectively
Gastrointestinal stromal tumors: clinicopathological study of Chinese cases.
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In the present study, we reviewed 73 Chinese cases of gastrointestinal stromal tumor (GIST), and analyzed factors in evaluating malignant potential, in particular focusing on Ki-67 index and p53 expression to determine whether these can be used as prognostic indicators in GIST. The p53 positive rate
Anti-inflammatory activity of traditional Chinese medicinal herbs.
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Accumulating epidemiological and clinical evidence shows that inflammation is an important risk factor for various human diseases. Thus, suppressing chronic inflammation has the potential to delay, prevent, and control various chronic diseases, including cerebrovascular, cardiovascular, joint, skin,
Papules and necrosis on both lower legs after topical use of Chinese herbs
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Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica.
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Psoriasis is a common, chronic, recurrent inflammatory skin disorder whose etiology is still unknown. It is believed that a multiple-gene inheritance is involved and it also involves various factors such as immunity, inflammation, cell proliferation, apoptosis, neural media, etc. Since cytokines are
Four tumor necrosis factor alpha genes polymorphisms and periodontitis risk in a Chinese population.
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BACKGROUND
Tumour necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of generalized aggressive periodontitis (AgP) and chronic periodontitis (CP). The objective of the present study was to evaluate the association of four TNF-alpha gene polymorphisms (-1031T/C, -857C/T,
Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
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OBJECTIVE
The purpose of this study was to examine whether polymorphisms of interleukin-4 (IL-4) (promoter-590 and intron 3) and tumor necrosis factor-alpha (TNF-alpha) promoter-308 genes are markers of susceptibility to or clinical manifestations of gout in Taiwanese patients.
METHODS
The study
Antitumor activities and tumor necrosis factor producibility of traditional Chinese medicines and crude drugs.
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The antitumor activities and capacity for tumor necrosis factor (TNF) production of traditional Chinese herbal preparations (Zhu-ling-tang, Xiao-chai-hu-tang), crude drugs (Polyporus, Hoelen, Bupleuri radix, Angelica radix, Cnidii rhizoma, Cinnamomum cortex), and Krestin (PSK) were investigated.
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