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cimicifugoside/actaea
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Simultaneous determination of cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside in beagle dog plasma by LC-MS/MS.
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A selective and sensitive LC-MS/MS method was developed and validated for the simultaneous determination of five constituents (cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside) of Cimicifuga foetida L. in beagle dog plasma. The
Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats.
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BACKGROUND
Cimicifuga foetida L., a traditional Chinese medicine, has been used as an anti-inflammatory, antipyretic and analgesic remedy. The primary active constituents are believed to be present in the triterpene glycoside fraction.
METHODS
To develop an LC-MS/MS assay for four major
Phytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells.
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We investigated the effect of the phytoestrogen cimicifugoside, one of the pharmacologically active ingredients of the medicinal plant Cimicifuga racemosa (black cohosh) that has been used to treat many kinds of neuronal and menopausal symptoms, such as arthritis, menopausal depression, and nerve
Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex.
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Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, which has been used as a traditional Chinese medicine due to its anti-inflammatory, analgesic or anti-pyretic action, was examined for inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity.
Six new cycloartane triterpene glycosides from Actaea asiatica.
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Six new cycloartane triterpene glycosides, (3',12beta)-O-diacetyl-cimigenol-3-O-beta-D-xylopyranoside (1), (4',25)-O-diacetyl-cimigenol-3-O-beta-D-xylopyranoside (2), 2'-O-acetyl-25-O-methyl-cimigenol-3-O-beta-D-xylopyranoside (3), 2'-O-acetyl-25-O-ethyl-cimigenol-3-O-beta-D-xylopyranoside (4),
Cycloartane triterpene saponins from the roots of Cimicifuga foetida.
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The structures of two new cycloartane-type saponin constituents of the roots of Cimicifuga foetida were established by the interpretation of spectroscopic data as 2'-O-acetylactein (1) and 2'-O-acetyl-27-deoxyactein (2), respectively. Also isolated were the known compounds actein, 27-deoxyactein,
[Cycloartane triterpenoid of Cimicifuga foetida].
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OBJECTIVE
To study cycloartane triterpenoid of Cimicifuga foetida and their osteoclast inhibition activity.
METHODS
The compounds were isolated and purified by normal and reversed phase column chromatographic methods. Structures were identified by spectroscopic analyses. Their osteoclast inhibition
Analysis of terpene compounds in Cimicifuga foetida L. by reversed-phase high-performance liquid chromatography with evaporative light scattering detection.
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An RP-HPLC method with evaporative light scattering detection (ELSD) was developed for the analysis of terpene compounds in traditional Chinese medicine. Actein, 27-deoxyactein and cimicifugoside in a typical Chinese medicine of Cimicifuga foetida L. were quantitatively analyzed. Comparing ELSD with
Triterpenoid glycoside from Cimicifuga racemosa.
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One new triterpene glycoside, cimiracemoside , and 14 known triterpene glycosides have been isolated from the rhizome extracts of black cohosh (Cimicifuga racemosa). On the basis of spectral and chemical evidence, the structure of the new compound was elucidated to be
Chlorination diversifies Cimicifuga racemosa triterpene glycosides.
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Extracts from the roots and rhizomes of black cohosh (Cimicifuga racemosa) are widely used as dietary supplements to alleviate menopausal symptoms. State-of-the-art quality control measures involve phytochemical fingerprinting of the triterpene glycosides for species identification and chemical
Selective inhibition of nucleoside transport into mouse lymphoma L-5178Y cells by cimicfugoside.
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Cimicifugoside, a triterpenoid from Cimicifuga simplex, is a potent inhibitor of thymidine-3H uptake by Raji cells, L-cells cl 1D cells, HeLa S3 cells and L-5178Y cells without affecting the growth rate of any cell type tested. It has also inhibited the uptake of purine and pyrimidine ribosides and
[Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials].
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The occurrence of vasomotor symptoms in women is directly related to deficiency of estrogen, which occurs as a result of natural or surgical menopause. Hot flushes may also be a major problem for patients with a history of breast cancer, as they may result directly from cancer treatment
Direct analysis and identification of triterpene glycosides by LC/MS in black cohosh, Cimicifuga racemosa, and in several commercially available black cohosh products.
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A method to directly identify triterpene glycosides using reversed-phase liquid chromatography with positive atmospheric pressure chemical ionization mass spectrometry (LC/(+)APCIMS) was developed. Based on the analysis of the molecular weight, fragment ions, selected ion chromatograms, a number of
Black cohosh: coming full circle?
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BACKGROUND
Black cohosh (Actaea racemosa L.), Ranunculaceae, thrives in temperate climates east of the Mississippi River in the USA. It is economically important to the Appalachian region where it is wild harvested, but it has resisted most efforts at deliberate cultivation. Black cohosh has been
[Studies on the constituents of Cimicifuga species].
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The chemical constituents of Cimicifuga simplex and its related species were reexamined using HPLC and high resolution spectral analysis. From C. simplex, C. acerina and C. japonica, a new alkaloid, 59 new cycloartane triterpene glycosides and 11 new aromatic constituents were isolated with the
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