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clerodendrum viscosum/dopamine
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Intractable chronic motor tics dramatically respond to Clerodendrum inerme (L) Gaertn.
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Tics are characterized by involuntary, sudden, rapid, repetitive, nonrhythmic, stereotyped movements or phonic productions. Those who suffer from either motor or phonic tics, but not both, for more than 1 year are diagnosed with chronic tic disorder. Several pharmacological interventions have been
Chemical and biological investigation of the root bark of Clerodendrum mandarinorum.
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A 70% EtOH extract of Clerodendrum mandarinorum root bark was assessed for CNS activity against 18 radioligand receptor binding assays. The results showed that the extract was able to bind to opiate, adenosine-1, alpha 2-adrenergic, 5HT-1, 5HT-2, dopamine-2, histamine-1, GABA(A), and GABA(B)
Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice.
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Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABAA receptors in the cerebellum.
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Hispidulin is a flavonoid we isolated from Clerodendrum inerme, an herb that effectively remitted a case of intractable motor tic disorders. Hispidulin was shown to be a positive allosteric modulator (PAM) of GABAA receptors, including the α6 subunit-containing subtype (α6GABAAR) that is
Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants.
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Extracts of Schefflera bodinieri and S. delavayi (Araliaceae), Celastrus angulatus and C. orbiculatus (Celastraceae), Clerodendrum mandarinorum and C. bungei (Verbenaceae), Periploca callophylla and P. forrestii (Asclepiadaceae), Alangium platanifolium (Alangiaceae) and Uncaria rhynchophylla
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