the study involves the intake of two capsules per day, one capsule to be taken before breakfast and one before dinner for a period of 6 weeks of a nutritional supplement
INTERVENTION CAPSULE COMPOSITION active substances for 2 capsules Bio Curcumin 400 mg Polydatin 00 mg Beta-Caryophyllene 48 mg

particpants included in the placebo group will take two capsules per day (containing no bioactive compound, only hydroxypropyl methylcellulose, gellan gum, pigment), one capsule to be taken before breakfast and one before dinner for a period of 6 weeks.

Osteoarthritis

Knee Pain Chronic

two capsules per day, one capsule to be taken before breakfast and one before dinner for a period of 6 weeks.

Experimental: Curcumin derivate

two capsules per day (containing no bioactive compound, only hydroxypropyl methylcellulose, gellan gum, pigment), one capsule to be taken before breakfast and one before dinner for a period of 6 weeks.

Placebo

Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis

Evaluation of the Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in People With Osteoarthritis

WOMAC scale is a self-administered questionnaire consisting of 24 items divided into 3 subscales:
Pain (5 items): during walking, using stairs, in bed, sitting or lying, and standing upright Stiffness (2 items): after first waking and later in the day Physical Function (17 items): using stairs, rising from sitting, standing, bending, walking, getting in / out of a car, shopping, putting on / taking off socks, rising from bed, lying in bed, getting in / out of bath, sitting, getting on / off toilet, heavy domestic duties, light domestic duties
The test questions are scored on a 0-4 scale, corresponding to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4).
The scores for each subscale are summed up; higher scores on the WOMAC indicate worse pain, stiffness, and functional limitations

Serum CRP levels were assessed by means of a commercially available CRP enzyme immunoassay

Levels of TNF-alpha, IL-1beta, IL-6, nitrates/nitrites will be evaluated by means of ELISA-testing

Painkillers utilization will be registered on a daily basis by participants, indicating dosage and daily frequency of use.

KOS Care SRL - Istituto di Riabilitazione Santo Stefano

Saffron treatment group received saffron tablets daily for 45 days

Barberry group received barberry tablets daily for 45 days

Placebo group received placebo tablets daily for 45 days

Metabolic Syndrome

Hypercholesterolemia

Hypertriglyceridemia

Hyperglycemia

Saffron tablet

Barberry tablet

Placebo tablets received daily for 45 days

Birjand University of medical sciences

Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) in Metabolic Syndrome

Effect of Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) on Metabolic Syndrome

Serum LDL cholesterol after 45 days of treatment in three study groups

Serum total cholesterol after 45 days of treatment in three study groups

serum HDL cholesterol after 45 days of treatment in three study groups

serum triglyceride after 45 days of treatment in three study groups

Fasting Blood Sugar after 45 days of treatment in three study groups

Hematocrit measured after 45 days of treatment

crocus sativus/antiinflamasi

Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis

Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) in Metabolic Syndrome

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