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The ambrosanolide cumanin inhibits macrophage nitric oxide synthesis: some structural considerations.
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Since its role in inflammatory diseases was recognized, nitric oxide (NO) has become an important mediator to evaluate anti-inflammatory agents. Sesquiterpene lactones, which occur in several medicinal plants, inhibit the NO production in macrophage-like cells. This action is probably due to a 1,4
Natural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatids.
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Among the natural compounds, terpenoids play an important role in the drug discovery process for tropical diseases. The aim of the present work was to isolate antiprotozoal compounds from Ambrosia elatior and A. scabra. The sesquiterpene lactone (STL) cumanin was isolated from A. elatior whereas two
Sesquiterpene lactones from Ambrosia spp. are active against a murine lymphoma cell line by inducing apoptosis and cell cycle arrest.
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Sesquiterpene lactones (STLs) are natural terpenoid compounds. They have been recognized as antitumor agents. The purpose of this investigation was to explore the antiproliferative effects of psilostachyin, psilostachyin C, peruvin and cumanin on the murine lymphoma cell line BW5147. Cells were
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