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cyclic amp/nekrosis

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This application is a 371 of PCT/GB93/00445, filed on Mar. 4, 1993. FIELD OF THE INVENTION This invention is directed to sulfur-containing aromatic compounds which are useful in inhibiting cyclic AMP phosphodiesterase or tumor necrosis factor. The invention is also directed to the preparation of

Compounds as PDE IV and TNF inhibitors

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FIELD OF THE INVENTION This invention is directed to [di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that

Compounds as PDE IV and TNF-inhibitors

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FIELD OF THE INVENTION This invention is directed to [di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that

Compounds as PDE IV and TNF inhibitors

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FIELD OF THE INVENTION This invention is directed to [di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that

Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds

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FIELD OF THE INVENTION This invention is directed to (aryl, heteroaryl, arylmethyl or heteroarylmethyl)] hydroxamic acid compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group

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FIELD OF THE INVENTION This invention is directed to substituted phenyl compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that mediate cellular activity. Disease states

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- o r

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FIELD OF THE INVENTION This invention is directed to substituted phenyl compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that mediate cellular activity. Disease states

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group

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FIELD OF THE INVENTION This invention is directed to substituted phenyl compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that mediate cellular activity. Disease states

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

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FIELD OF THE INVENTION This invention is directed to substituted phenyl compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that mediate cellular activity. Disease states

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

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FIELD OF THE INVENTION This invention is directed to substituted phenyl compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that mediate cellular activity. Disease states

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group

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FIELD OF THE INVENTION This invention is directed to substituted phenyl compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states associated with proteins that mediate cellular activity. Disease states
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