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cystadenocarcinoma/hypoxia
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Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma.
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There is evidence to suggest that follicle-stimulating hormone (FSH) can facilitate the neovascularization of ovarian cancers by increasing vascular endothelial growth factor (VEGF) expression in cancer cells, although the underlying molecular mechanism of this process is not well known. Therefore,
Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours.
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OBJECTIVE
Carbonic anhydrase (CA) isozymes IX and XII have been suggested to play a role in oncogenic processes. The aim of the present study was to investigate CA IX and XII expression in patients with ovarian tumours.
RESULTS
A series of ovarian tumours was immunostained for CA IX and XII and the
Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases.
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BACKGROUND
Lactate dehydrogenase A (LDHA) is involved in anaerobic glycolysis. In cancer patients, serum total lactate dehydrogenase (LDH) levels are often increased, and the gene for one of its isoenzymes, LDHA, is up-regulated. These features have been linked to poor prognosis in several
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