The experimental group will receive a parenteral emulsion containing soy oil, MCT, olive oil and n-3 LCPUFA in fish oil

The Control group will receive a parenteral emulsion containing soy oil and MCT

Pulmonary Hypertension of Newborn

Diaphragm Defect

TPN will start at 2.0 g/kg/d of the lipid emulsion, increasing 1.0 g/kg/d until a maximum of 4.0 g/kg/d for at least 14 days.

Parenteral emulsion

Unit of Medical Research in Nutrition

Effect of a Parenteral Emulsion With Omega3 on PPHN

Effect of a Parenteral Emulsion Parenteral With Long-chain Polyunsaturated Fatty Acids Omega 3 on Clinical Outcomes, Inflammatory and Oxidative Stress Markers in Neonates With Persistent Pulmonary Hypertension

measured by echocardiography in millimeters of mercury (mm/Hg)

Measure the amount of oxygen in blood measured by gasometry in arterial blood in mmHg

It is a measure of oxygenation in hemoglobin. It is preductal if the measurement id on hand, and postductal if it is on foot, determined by an pulse oximeter in percentage

Oxygen concentration supplied by ventilation support in percentage

Measurement of body weight in grams, length and head circumference in centimeters to obtain an eutrophic or undernutrition outcome using the Fenton's standard reference of growth and/or World Health Organization as appropriate for preterm or term infants, respectively.

Pain will be measured with COMFORT scale computed by the sum of 8 sections with scores from 1 to 5. The sum will be scored as mild (<10 points), moderate (10-20 points) and severe (>20 points)

Determination of pro and anti-inflammatory cytokines interleukin (IL)-1beta, tumoral necrosis factor-alpha, IL-6, IL-8, IL-10, IL-12 (p70) (pg/milliliter) in plasma by luminex-based immunoassay.

Determination lipid mediators such as eicosanoids and resolvin(s) in ng/ml by liquid chromatography coupled to mass spectrometry.

This will be measured in urine by ELISA in pg/milliliter

This will be measured in urine by ELISA in micromol per liter (uM)

This will be measured in urine by ELISA in uM/milliliter

This ratio will be measured in urine in nmol/liter by Liquid chromatography coupled to mass spectrometry.

Mariela Bernabe García

Full time researcher

Coordinación de Investigación en Salud, Mexico

Use of a parenteral emulsion that is used as routine nutrition for newborns but not evaluated for persistent pulmonary hypertension.

The attendant gastroenterologist has a randomized allocation and will indicate the type of emulsion during the recruitment. Each emulsion will be designed as a code A or B. The code for each patient is stored into an opaque envelop, which is opened once the parents have given their written informed consent.

Men and women admitted with chest pain and suspected acute coronary syndrome (ACS).

Serum, Citrated plasma, EDTA-plasma and packed red blood cells are kept in suitable aliquots at -80 degrees Celcius.

Patients recruited immediately following acute hospital admission for suspected coronary chest pain.

Patients With Suspected Acute Coronary Chest Pain

Sex: Female, Male

Region of Enrollment

Patients with acute hospitalisation due to suspected coronary chest pain.

Patients With Suspected ACS

Total Mortality.

Cardiovascular Death. Myocardial infarctions (re-MIs) defined according to WHO criteria of 1979.

Patients with confirmed cardiovascular death during the course of the study

Cardiovascular Death

Patients with one or more myocardial re-infarctions during the course of the study

Myocardial Re-infarction

Participants With Cardiac Events During Follow-up.

Overall Study

Dennis WT Nilsen, MD, phd, professor

Patients admitted to hospital with acute chest pain.

Chest Pain

Coronary Artery Disease

Unstable Angina Pectoris

Myocardial Infarction

Clinica Güemes

Clinica San Rafael

Hospital Militar Salta

Hospital Privado Santa Clara de Asis

Hospital San Bernardo

Intituto CENESA

Sanatorio El Carmen

Sanatorio El Parque

Sanatorio San Roque

Stavanger University Hospital

ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study

ARgentinean Risk Assessment Registry in Acute Coronary Syndrome; the ARRA-RACS Study.

Helse Stavanger HF

Universidad Católica de Salta

Men and women admitted with chest pain and a suspicious acute coronary syndrome (ACS)

Group 1

Recurrent Troponin-T (TnT) positive events; Symptoms of coronary ischemia associated with TnT >0.05 ng/mL with a pattern of gradual rise and fall in TnT

docosahexaenoic acid/hypoxia

Effect of a Parenteral Emulsion With Omega3 on PPHN

ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study

Risk Markers in the Acute Coronary Syndromes

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