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Biocompatibility and effectiveness of paclitaxel-encapsulated micelle using phosphoester compounds as a carrier for cancer treatment.
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Phosphoester compounds are promising materials with expected biocompatibility; however, little has been reported on the use of phosphoester compounds for micelle formulations. In this study, paclitaxel (PTX)-encapsulated micelles were prepared using four kinds of alkyl di(MePEG-lactate) phosphates.
Analysis of brefeldin A in plasma by gas chromatography with electron capture detection.
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The National Cancer Institute (NCI) is pursuing preclinical development of Brefeldin A (BFA), a macrolide isolated from Penicillium brefeldianum, as an antitumor agent. BFA exhibits a unique spectrum of activity against the human tumor cell line panel that composes the NCI's recently established in
Antitumor activity of kielmeyera coriacea leaf constituents in experimental melanoma, tested in vitro and in vivo in syngeneic mice.
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OBJECTIVE
The antitumor activity of Kielmeyera coriacea (Clusiaceae), a medicinal plant used in the treatment of parasitic, as well as fungal and bacterial infections by the Brazilian Cerrado population, was investigated.
METHODS
A chloroform extract (CE) of K. coriacea was tested in the murine
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