This group will be treated with medication alone (amitriptyline hydrochloride, 25 mg) for chronic vulvar pain (vulvodynia).

This group will be treated with medication (amitriptyline hydrochloride, 25 mg) plus pelvic floor exercises such as Kegel contractions and stretching of pelvic floor muscles with patients own hands.

This group will be treated with medication (amitriptyline hydrochloride, 25 mg) plus electrical stimulation with Interferential Current (manufacturer: Quark Medical; Model: Dualpex 961 - program number 42): two electrodes put into the perineal surface area emitting interferential current, once a week for twenty minutes each, for eight weeks long.

Vulvodynia

Volunteers will take 25 milligrams of this medication every day from their enrollment until completing eight weeks long.

Amitriptyline

Volunteers will be taught to contract their pelvic floor muscles right before stretching it, following a home protocol, every day for eight weeks long.

Kinesiotherapy

Volunteers will visit physical therapy clinic once a week to receive twenty minutes of electrical stimulation with Interferential Current (Duapex 961 of Quark Medical manufacturer) in their perineal area, for eight weeks long.

IC (Quark)

Unicamp

Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial

Effectiveness of the treatment for vulvodynia will be accessed through pain score scale from zero to ten, compared from day zero of treatment to day eight

Will be accessed through FSIF (Female Sexual Index Function questionnaire) score that goes from 2 to 36, compared from day zero of treatment to day eight, which indicates sexual disfunction pointed by scores below 26,55.

A 3D Ultrassound will be used to access these outcomes and compare changes from day zero to day eight of treatment

Vaginal fluid collected will be analysed in laboratory to access possible inflammatory response of vulva and vagina of women with vulvodynia obtained by comparing quantitatively interleukin 1-B presente before and after treatment

Marcela Grigol Bardin

Master in Obstetrics and Gynecology

University of Campinas, Brazil

Participants are identified through relevant diagnostic codes in ICD-10(Q 42) and ICD-9(75.120, 75.121) in patients which underwent surgery for ARM in the years 1985-2005 are included if informed consent is obtained.
Relevant questionnaires regarding symptoms and QoL are completed before the following examinations:anorectal manometry, endoanal ultrasonography, pudendal nerve conduction velocity, colon transit time, Magnetic resonans(MR)-scan of the pelvis and uroflowmetry.

Anorectal Malformation

Long-term Outcome in Patients With Anorectal Malformations

Long-term Outcome in Patients Operated for Congenital Anorectal Malformations

Thomas Bjørsum-Meyer

M.D.,ph.d-student

Odense University Hospital

Aarhus University Hospital

University of Southern Denmark

Uterine Cancer

Ovarian Cancer

Fallopian Tube Cancer

Peritoneal Cancer

Cervical Cancer

Vulvar Cancer

Survey

Abramson Cancer Center of the University of Pennsylvania

Pelvic Floor Disorders in Survivors of Gynecologic Malignancies

The Prevalence and Predictive Factors of Pelvic Floor Disorders in Gynecologic Malignancy Survivors

Urinary incontinence is the most common outcome of all symptomatic pelvic floor disorders in women

Supervised exercise training at the hospital during pregnancy: the women will attend at least 2 weekly sessions consisting of aerobic exercise (walking on treadmills), strength training (for upper body, back, abdomen and legs) as well as pelvic floor muscle exercises. Each session is 60 minutes and lead by a physiotherapist or experienced exercise physiologist. The women will also go through motivational interviewing sessions throughout the intervention period and are encouraged to do home exercise training in addition to the exercise at the hospital

Usual care as provided by the health services in Norway. The investigators will not advice the women to be inactive

Pregnancy

Obesity

Exercise

Norwegian University of Science and Technology

Exercise Training in Pregnancy for Obese Mothers

Exercise Training in Pregnancy. Good for the Mother - Good for the Child?

Blood samples to determine the fasting glucose after an overnight fast (>10 hours)

2 hour 75 mg per-oral glucose tolerance test. Gestational diabetes is diagnosed as fasting glucose = or > 6.9 mmol/L or 2h concentration = or > 7.8 mmol/L.

Skinfold measurements, done by an experienced investigator using Harpenden kaliper. At the 3 months postpartum testing, also dual energy x-ray absorptiometry (DEXA scan) will be used.

Inflammation markers, cytokines (leptin, resistin, adiponectin, tnf-alfa). Blood will be collected and stored for later analyses.

Clinical assessment (active straight leg raising, pelvic provocation test), and validated questionnaire.

Pelvic floor muscle function will be assessed by clinical assessment and by 2D and 3D ultrasound. The prevalence and severity of urin- and fecal incontinence will also be assessed by a validated questionnaire

Level of physical activity will be assessed by activity registration (armbands) and by validated questionnaires

Vaginal or caesarean delivery, and recorded complications during the delivery

Cord blood will be sampled and stored for later analysis of relevant markers of inflammation and metabolism (including resistin, leptin, adiponectin)

fecal incontinence/obesitas

Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial

Long-term Outcome in Patients With Anorectal Malformations

Pelvic Floor Disorders in Survivors of Gynecologic Malignancies

Exercise Training in Pregnancy for Obese Mothers

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