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hepatitis c/protease
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Reporter gene system for use in cell-based assessment of inhibitors of the Hepatitis C virus protease
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TECHNICAL AND INDUSTRIAL APPLICABILITY OF INVENTION
A cell-based assay system in which the detection of reporter gene activity (secreted alkaline phosphatase or SEAP) is dependent upon active Hepatitis C virus (HCV) NS3 protease. The assay system is useful in the in vitro screening, in a mammalian
Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease
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TECHNICAL AND INDUSTRIAL APPLICABILITY OF INVENTION
A cell-based assay system in which the detection of reporter gene activity (secreted alkaline phosphatase or SEAP) is dependent upon active Hepatitis C virus (HCV) NS3 protease. The assay system is useful in the in vitro screening, in a mammalian
Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease
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TECHNICAL AND INDUSTRIAL APPLICABILITY OF INVENTION
A cell-based assay system in which the detection of reporter gene activity (secreted alkaline phosphatase or SEAP) is dependent upon active Hepatitis C virus (HCV) NS3 protease. The assay system is useful in the in vitro screening, in a mammalian
Imidazolidinones and their related derivatives as hepatitis C virus NS3 protease inhibitors
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FIELD OF THE INVENTION
The present invention relates generally to a novel class of imidazolidinones that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds
Process for making macrocyclic oximyl hepatitis C protease inhibitors
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TECHNICAL FIELD
The present invention relates to an improved process for the preparation of macrocyclic compounds that are useful as hepatitis C virus (HCV) protease inhibitor compounds.
BACKGROUND OF THE INVENTION
HCV is the principal cause of non-A, non-B hepatitis and is an increasingly severe
Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus
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FIELD OF INVENTION
The present invention relates to novel hepatitis C virus ("HCV") protease inhibitors, pharmaceutical compositions containing one or more such inhibitors, methods of preparing such inhibitors and methods of using such inhibitors to treat hepatitis C and related disorders. This
Peptides and their use as inhibitors of hepatitis C virus ns3 protease
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FIELD OF THE INVENTION
This invention relates to compounds which can act as inhibitors of the hepatitis C virus (HCV) NS3 protease, to uses of such compounds and to their preparation.
BACKGROUND OF THE INVENTION
The hepatitis C virus (HCV) is the major causative agent of parenterally-transmitted and
Processes for preparing protease inhibitors of hepatitis C virus
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REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY
The sequence listing of the present application is submitted electronically via EFS-Web as an ASCII formatted sequence listing with a file name "MRLIFD22448USPCT-SEQLIST-09MAY2012.TXT" and a size of 1023 bytes. This sequence listing submitted
Pharmaceutical composition for a hepatitis C viral protease inhibitor
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FIELD OF THE INVENTION
The present invention relates in general to a pharmaceutical composition of a hepatitis C viral protease inhibitor, methods of using this composition for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection.
BACKGROUND OF THE
Hepatitis C surrogate virus for testing the activity of hepatitis C virus protease, a recombinant gene and a use thereof
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a hepatitis C virus (HCV), more particularly, is related to a hepatitis C surrogate virus which comprises poliovirus genome, HCV protease and its target site, and is suitable for testing efficacy of anti-HCV drugs
Inhibitors of hepatitis C virus NS3 protease
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FIELD OF THE INVENTION
The present invention relates generally to a novel class of pyrimidinones that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds
Peptide inhibitors of hepatitis C virus NS3 protease
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FIELD OF THE INVENTION
The present invention relates generally to a novel class of peptides, which are useful as serine protease inhibitors, and more particularly as Hepatitis C virus (HCV) NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds
Pharmaceutical compositions for hepatitis C viral protease inhibitors
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FIELD OF THE INVENTION
The present invention relates in general to pharmaceutical compositions of hepatitis C viral protease inhibitors, methods of using these compositions for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection.
BACKGROUND OF THE
Peptide inhibitors of hepatitis C virus NS3 protease
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TECHNICAL FIELD
This invention relates to compounds which can act as inhibitors of the hepatitis C virus (HCV) NS3 protease, to uses of such compounds and to their preparation.
BACKGROUND ART
The hepatitis C virus (HCV) is the major causative agent of parenterally-transmitted and sporadic non-A,
Hepatitis C virus NS3 protease inhibitors
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FIELD OF THE INVENTION
The present invention relates to macrocyclic compounds that are useful as inhibitors of the hepatitis C virus (HCV) NS3 (non-structural 3) protease, their synthesis, and their use for treating or preventing HCV infection.
BACKGROUND OF THE INVENTION
Hepatitis C viral infection
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