Four day dietary intervention immediately before surgery of ScandiShake [any of 4 flavors] mixed with almond milk, calculated individually for a total daily volume to achieve 30% caloric restriction and 70% protein restriction, based on body weight and activity level.

Ad libitum diet for four days immediately before surgery

Vascular Diseases

Surgery

Protein-Calorie Restriction

Brigham and Women's Hospital

Dietary Restriction in Vascular Surgery

Patient compliance with the PCR diet will be assessed by food record analysis.

Biologic markers include: adipose phenotyping (quantification of adipokines, adipose derived hormones), leukocyte phenotyping and quantification via flow cytometry, and serum assays of IL-1beta, IL-6, IL-8, HGF, leptin, MCP-1, PAI-1, resistin, NGF, TNF, adiponectin, hydrogen sulfide (including production capacity) assays, insulin, lipid panels, FGF 21, pre-albumin, epinephrine, norepinephrine, dopamine, CBC with differential, basic metabolic panel including calcium. H2S and biologic markers will be compared at baseline, immediately before surgery, and the day after surgery.

C. Keith Ozaki, M.D., F.A.C.S.

John A. Mannick Professor of Surgery

3:2 randomization to short-term protein calorie restriction diet versus regular meals prior to elective major vascular surgery

Mortality

Shock

University Medical Center

Hydrogen Sulfide as Prognostic Factor

relationship between H2S and mortality of patients during intensive care treatment,
comparison of H2S and lactate prognostic value

relationship between H2S and dose of vasopressors (noradrenaline, epinephrine) used

hydrogen sulfide/stroke

Dietary Restriction in Vascular Surgery

Hydrogen Sulfide as Prognostic Factor

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