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hyperalgesia/radang
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Agents for treating neurogenic inflammation and neuropathic hyperalgesia related disorders
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This is the national stage of International Application PCT/HU2014/000097, filed Oct. 28, 2014.
FIELD OF THE INVENTION
The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the general formula (I) and solvates, hydrates and pharmaceutically acceptable salts
Method of treatment or prophylaxis of inflammatory pain
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FIELD OF THE INVENTION
This invention relates generally to compounds that are useful in the prevention and amelioration of signs and symptoms associated with inflammatory pain. More particularly, the present invention relates to the use of angiotensin II receptor 2 (AT.sub.2 receptor) antagonists
Method of treatment or prophylaxis of inflammatory pain
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PRIORITY DATA AND INCORPORATION BY REFERENCE
This is a National Stage application under 35 U.S.C. 371 of International Application No. PCT/AU2007/000339, filed Mar. 20, 2007, which claims the benefit of priority to AU Application No. 2006901413 filed Mar. 20, 2006, the entireties of which are hereby
Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation
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This is the national stage of International Application PCT/HU2014/000127, filed Dec. 18, 2014.
TECHNICAL FILED OF THE INVENTION
The present invention is based on potent analgesic (anti-hyperalgesic) effect of semicarbazide-sensitive amine oxidase (SSAO) also known as vascular adhesion protein 1
Compositions and methods for inhibition of phospholipase A2 mediated inflammation
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FIELD OF THE INVENTION
The present invention relates generally to the field of non-steroidal anti-inflammatory agents for inhibition of phospholipase A2 enzymes, and the use of such agents in controlling inflammation.
BACKGROUND OF THE INVENTION
Injury to one part of the body often results in
Use of precursors of tachykinins and/or their fragments in medical diagnostic
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a 371 filing of PCT International application no. PCT/EP2005/004254 filed Apr. 20, 2005 and published in English as WO 2005/103712 on Nov. 3, 2005 which claims the priority of European application no. 040009284.3 filed Apr. 20, 2004. The
Use of precursors of tachykinins and/or their fragments in medical diagnostic
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The present invention relates to the use of protachykinin and/or its fragments and/or its splice variants, fragments comprising protachykinin and/or combinations thereof in medical diagnostics. In the following text all these molecules, fragments, combinations thereof etc. are referred to as
Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
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FIELD OF INVENTION
The present invention relates to spirochromane compounds of formula (I), which are useful for treating disorders caused by or exacerbated by vanilloid receptor type 1 (VR1) activity. The present invention also includes pharmaceutical compositions containing compounds of formula
Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
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FIELD OF INVENTION
The present invention relates to spirochromane compounds of formula (I), which are useful for treating disorders caused by or exacerbated by vanilloid receptor type 1 (VR1) activity. The present invention also includes pharmaceutical compositions containing compounds of formula
Bradykinin receptor modulators and use thereof
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This application is the national stage entry under 35 U.S.C. .sctn. 371 of International Application No. PCT/IB2014/001162, filed on Jun. 24, 2014, which claims priority to Swiss Application No. 01168/13, filed Jun. 25, 2013. The contents of these applications are each incorporated herein by
Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold
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TECHNICAL FIELD OF THE INVENTION
BACKGROUND OF THE INVENTION
Nitric oxide (NO), which serves as an intracellular messenger, is implicated in a number of processes in the central nervous system. In the spinal cord, considerable evidence has demonstrated that NO contributes to the development of
Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold
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TECHNICAL FIELD OF THE FIELD INVENTION
BACKGROUND OF THE INVENTION
Nitric oxide (NO), which serves as an intracellular messenger, is implicated in a number of processes in the central nervous system. In the spinal cord, considerable evidence has demonstrated that NO contributes to the development of
Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold
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BACKGROUND OF THE INVENTION
Nitric oxide (NO), which serves as an intracellular messenger, is implicated in a number of processes in the central nervous system. In the spinal cord, considerable evidence has demonstrated that NO contributes to the development of hyperalgesia in models of acute and
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
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TECHNICAL BACKGROUND
The present invention relates to compounds of formula (I), which are useful for treating disorders caused by exacerbated by or vanilloid receptor activity, pharmaceutical compositions containing compounds of formula (I) and are useful in treating pain, bladder overactivity, and
Bradykinin B1 receptor antagonists
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FIELD OF THE INVENTION
The invention relates to pyrimidines, triazines, and anilines that are bradykinin B.sub.1 -receptor antagonists. The compounds are useful for treating diseases associated with inappropriate or excessive bradykinin receptor activity, such as diabetic vasculopathy, inflammation,
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