oral supplementation with a mixture of amino essential acids 8 gr die in two administrations for six weeks

placebo consisting in isocaloric product containing maltodextrins in two administrations for six weeks

Stroke Rehabilitation

Amino Essential Acid

placebo

ICS Maugeri IRCCS, U.O. di Rieducazione e Recupero Funzionale di Montescano

Effects of Supplementation With Amino Essential Acids on Circulating Albumin Levels in Stroke in Rehabilitation Phase

Effects of Supplementation With Amino Essential Acids on Circulating Albumin Levels in Patients With Cerebral Ictus in Rehabilitation Phase

Number of patients who at discharge show levels of albuminemia> 0.35 gr / dl (normal level)

The Functional Independence Measure (FIM) is an 18-item measurement tool that explores an individual's physical, psychological and social function. The tool is used to assess a patient's level of disability. Range total FIM score 18-126. High score corresponds to better outcome.

Istituti Clinici Scientifici Maugeri SpA

University of Pavia

Control Treatment with Oral Glucose Tolerance Test:
Blood glucose and insulin will be obtained following the protocol of Eicher et al (4). Participants will ingest a Placebo (inert, calorie free, stevia sweetener) with blood collections at 0,2,4,6,8,10,30 prior to a standard 75 g glucose solution, followed by blood collections at 0,2,4,6,8,10,30,60,90,120 minutes post glucose ingestion. A total of 16 blood collections will be taken.

Control Treatment with Oral Glucose Tolerance Test:

Isoleucine Combined with Oral Glucose Tolerance Test:

Leucine and Isoleucine Combined with Oral Glucose Tolerance Test:

Hyperglycemia

For this visit participants will ingest a powdered form of Leucine in the amount of 0.3g/kg of lean body mass weight with water (150 mL) with additional water if needed to ensure dose is fully consumed. The amino acid solution will be ingested 30 min prior to 75 g glucose solution

Leucine Supplement

For this visit participants will ingest a powdered form of Isoleucine in the amount of 0.3g/kg of lean body mass weight with water (150 mL) with additional water if needed to ensure dose is fully consumed. The amino acid solution will be ingested 30 min prior to 75 g glucose solution.

Isoleucine Supplement

For this visit participants will ingest a powdered form of Leucine and Isoleucine in the amount of 0.3g/kg of lean body mass weight (equal in total dosage to other treatments) with water (150 mL) with additional water if needed to ensure dose is fully consumed. The amino acid solution will be ingested 30 min prior to 75 g glucose solution.

Leucine Supplement combined with Isoleucine Supplement

The Effects of Leucine and Isoleucine on Glucose Metabolism

Texas Woman's University

Patients with subacute stroke in a neurorehabilitation setting.

Muscle Weakness

Sham IMT at a fixed workload of 10 cmH2O. 5 sets of 10 repetitions, twice a day, 7 days per week, for 4 weeks.

Inspiratory Muscle Training (IMT)

High Intensity IMT. The training load is the maximum inspiratory load defined according to patient tolerance. This load will be equivalent to 10 maximal repetitions (RM) as 10 consecutive inspirations (x 5 sessions), twice a day.

High-intensity IMT

Physical Medicine and Rehabilitation Dpt. Parc de Salut Mar, Hospital del Mar

Respiratory Muscle Training in Subacute Stroke Patients

The RETORNUS Study: Dual Training to Restore the Function of Respiratory Muscles in Stroke Patients

Respiratory muscle strength is assessed through maximal inspiratory and expiratory pressures (MIP and MEP, respectively) using a pressure transducer connected to a digital register system. The MIP is measured at mouth during a maximum effort from residual volume against occluded airway. To determine the MEP, the patients will perform a maximum expiratory effort from total lung capacity (TLC) in the face of the occluded airway. A specific and validated respiratory pressures manometer will be used (Micro RPM, Cardinalhealth, Kent, UK). For the purposes of the study, 'responders' will include the group of patients with an increase of 25% or more in respiratory muscle strength (MIP and MEP).
Measures will be done once every week

Handgrip strength will be assessed during maximal voluntary isometric contraction of the flexor muscles of the fingers, using a dynamometer (JAMAR, Nottinghamshire, UK). We consider both the non-dominant and dominant hand. Reference values are those from Webb et al. (J Par Ent Nutr 1989, 13:30-3).
Measures once every week

Lower limb strength will be measured during a maximal voluntary isometric knee extension while the patient is sit in a bank of exercise (DOMYOS HG 050, Decathlon, France). An isometric dynamometer Nicholas Manual Muscle Tester (NMMT) (Lafayette Instrument Company, Lafayette, Indiana) will be used according to Dunn JC (J Phys Ther Ger 2003).
Measures once every week

Analysis of plasma samples (high performance liquid chromatography (HPLC) will determine levels of glutamine, valine, isoleucine, leucine and glutamate at baseline and at the end of muscle training using the technique previously described and validated (Clin Chem 1988, 34 (12): 2510-3). Venous blood samples will be collected in heparinized tube and centrifuged to obtain plasma. Later proceed to deproteinization with sulfosalicylic acid for analyzing the concentration of amino acids (AA). Finally the sample will be frozen at -80 º C for further analysis.

Comorbidity variables (occurrence of complications, hospital admissions, hospital length of stay) and mortality.

isoleucine/stroke

Effects of Supplementation With Amino Essential Acids on Circulating Albumin Levels in Stroke in Rehabilitation Phase

The Effects of Leucine and Isoleucine on Glucose Metabolism

Respiratory Muscle Training in Subacute Stroke Patients

Database tanaman obat terlengkap yang didukung oleh sains