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ketoglutaric acid/seizures

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Protection from hyperbaric oxygen intoxication by some derivatives of alfa-ketoglutaric acid.

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A study was made of the protective effects afforded by some derivatives of alpha-ketoglutaric acid in hyperbaric oxygen intoxication. The research performed shows that these substances are able either to prevent convulsions (Paul Bert phenomenon) or to prolong the survival of treated animals. Brain

Lactic acidosis in three sibs due to defects in both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes.

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A Canadian Indian family is described in which three of the children were mentally retarded, and had seizures and other neurological abnormalities. They had chronic metabolic acidosis associated with elevated blood levels of lactate, pyruvate, and alanine. Two of the children excreted large amounts

Biotin-responsive infantile encephalopathy: EEG-polygraphic study of a case.

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A case of an infant suffering from progressive lethargy, sparse scalp hair, autistic-like behavior, myoclonias, and drug-resistant generalized seizures is reported. Laboratory investigations revealed, in the absence of metabolic acidosis, an increased urinary excretion of 2-ketoglutaric acid and a
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