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laburnum anagyroides/nikotin
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Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS.
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We report about a fatal cytisine intoxication in a 20-year-old man who, according to his mother, had drunken tea prepared from plant material of Laburnum anagyroides with the toxic pyridine-like alkaloid as ingredient, which exhibits pharmacological effects similar to nicotine. Using a liquid
Qualitative and quantitative variation among volatile profiles induced by Tetranychus urticae feeding on plants from various families.
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Many plant species are known to emit herbivore-induced volatiles in response to herbivory. The spider mite Tetranychus urticae Koch is a generalist that can feed on several hundreds of host plant species. Volatiles emitted by T. urticae-infested plants of 11 species were compared: soybean (Glycine
(+)-Laburnamine, a natural selective ligand and partial agonist for the α4β2 nicotinic receptor subtype.
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(+)-Laburnamine (1), a rare alkaloid extracted from Laburnum anagyroides seeds (∼4 mg from 1 kg), was shown to bind with high affinity (Ki, 293 nM) to the α4β2 nicotinic receptor subtype, which is, respectively, 126 and 136 times higher than to the α3β4 (Ki 37 μM) and α7 subtypes (Ki 40 μM). When
Cytisine's potential to be used as a traditional healing method to help indigenous people stop smoking: a qualitative study with Māori.
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BACKGROUND
Māori experience a disproportionate amount of smoking-related harm (46% of adult Māori smoke). Effective cessation treatments that are both accessible and attractive to Māori are urgently needed. Cytisine (a plant extract found in Golden Rain [Cytisus laburnum L.] and the New Zealand
Nicotinic plant poisoning.
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BACKGROUND
A wide range of plants contain nicotinic and nicotinic-like alkaloids. Of this diverse group, those that have been reported to cause human poisoning appear to have similar mechanisms of toxicity and presenting patients therefore have comparable toxidromes. This review describes the
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