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Silymarin in COVID-19 Pneumonia

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To date, there are no drugs or other therapeutics approved by the U.S. Food and Drug Administration (FDA) to prevent or treat COVID-19 that has spread globally resulting in the ongoing pandemic as declared by the World Health Organization (WHO) on 11 March 2020. While the majority of patients have

Milk Thistle in Trichotillomania in Children and Adults

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Pathological hair-pulling, trichotillomania, has been defined as repetitive, intentionally performed pulling that causes noticeable hair loss and results in clinically significant distress or functional impairment. Trichotillomania appears relatively common with an estimated prevalence between 1-3%.

Milk Thistle in Pathological Gambling

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Gambling disorder is a significant public health problem that often results in a distinctive pattern of persistent and disabling psychological symptoms. Although once thought to be relatively uncommon, studies estimate that gambling disorder has a lifetime prevalence among adults of 1.6% and

The Effect of Protandim Supplementation on Oxidative Damage and Athletic Performance

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Forty apparently healthy community runners 18-55 yrs of age was recruited to participate in this study that will require six total visits to the University of Louisville, which included three sessions at the running track at University of Louisville. A about 120 mL of blood was withdrawn from a

THISTLE - The HIV-HCV Silibinin Trial

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Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma

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This study will look for possible protective effects silymarin on kidney injury in patients receiving cisplatin.

Immunomodulatory Effects of Silymarin in Patients With Beta-Thalassemia Major

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N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy

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Oxidative stress and glutathione (GSH) imbalance are major contributors to the pathogenesis of diabetic nephropathy. Current options for the treatment of oxidative stress in diabetic nephropathy are limited and only partially effective, thus interest in the development of new strategies is high. The

Siliphos in Advanced Hepatocellular Carcinoma

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Milk thistle (MT) has been historically used to treat patients with liver diseases, and has been shown to have antioxidant, anti inflammatory, and hepatoprotective properties. It may also have direct anticancer effects through inhibition of growth factors and promotion of cell cycle arrest. MT has

Comparative Effects of Milk Thistle Extract With Vitamin-E in Hemodialysis Patients

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The Effect of Protandim on Non-alcoholic Steatohepatitis

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N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy

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Oxidative stress and GSH imbalance are major contributors to the pathogenesis of diabetic nephropathy. Current options for the treatment of oxidative stress in diabetic nephropathy are limited and only partially effective, thus interest in the development of new strategies is high. The study intends

Randomized Controlled Trial of Silymarin in Asthma

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SPECIFIC AIMS Dietary intake of exogenous antioxidants has been shown to have only a modest impact on asthma inception and control. Our work has demonstrated that endogenous antioxidant enzyme concentrations are a far stronger predictor of asthma inception compared with dietary antioxidant intake

An Assessment of Milk Thistle Pharmacokinetics and Drug Interactions

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BIOAVAILABILTY STUDY: 1. Clinical Protocol Screening/Informed Consent: Sixteen subjects will be recruited for the clinical protocol. All protocols, consent forms, and HIPAA forms shall be IRB-approved prior to initiating any study procedure or recruitment. At a screening/informed consent visit, the

Silymarin (Milk Thistle Extract) in Treating Patients With Acute Lymphoblastic Leukemia Who Are Receiving Chemotherapy

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OBJECTIVES: - Determine the effect of silymarin, in terms of liver function tests, in patients with acute lymphoblastic leukemia receiving hepatotoxic chemotherapy. - Determine the effect of this drug on free and conjugated serum silibinin values in these patients. - Determine the serum antioxidant

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