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15 hasil
How does lobeline injected intravenously produce a cough?
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In order to examine, whether the lobeline-induced cough is a true reflex or a voluntary effort to get rid of its irritating sensations in the upper respiratory tract, we systematically studied the cough response to lobeline, of subjects who were unable to make conscious discriminations i.e. were
[IS INTRAVENOUS LOBELINE INJECTION AN AID FOR WHOOPING COUGH DIAGNOSIS?].
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[Provocation of typical whooping cough attacks by intravenous injection of lobeline].
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[Experimental study, in the chloralosed cat, of the antitussive effects of two synthetic antihistaminics, by means of the pleurotussigenic reflex & lobeline cough].
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[Experimental study, in the chloralosed dog, of the antitussive effects of codeine, by means of the pleuro-tussigenic reflex and lobeline-induced cough].
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Influence of codeine on lobeline-induced respiratory reflexes and sensations and on ventilation with exercise in healthy subjects.
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In 15 healthy subjects, the effect of 60 mg oral codeine and placebo was examined on intravenously injected lobeline-elicited respiratory reflexes and sensations. Its influence was also studied on ventilation and appearance of distressful respiratory sensations with modest but incremental exercise.
[Pharmacological studies on the cough-like reflex induced by chemical stimulation (author's transl)].
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To investigate the mechanism of the cough-like reflex (CLR), we employed 1.1-dimethyl-4-phenylpiperazinium iodide (DMPP). In dogs anesthetized with alpha-chloralose, CLR was induced by administration of DMPP (i.v. and intracarotid arterial), lobeline and nicotine. Repeated administration of DMPP did
Sensory origin of lobeline-induced sensations: a correlative study in man and cat.
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1. Intravenous injections of lobeline HCl into twenty-six normal young male human volunteers produced sensations of choking, pressure or fumes in the throat and upper chest at a mean threshold dose of 12 micrograms kg-1. 2. Reflex changes in breathing pattern usually appeared just before the
Presence of lobeline-like sensations in exercising patients with left ventricular dysfunction.
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Since there is evidence that lobeline-induced sensations, associated with discomfort in the mouth, throat and chest arise by stimulating juxtapulmonary or J receptors, we were interested in investigating if similar sensations are felt by patients with left ventricular dysfunction (LVD) in whom a
Comparison of respiratory sensations induced by J receptor stimulation with lobeline in left handers & right handers.
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We examined the hypothesis that right handers and left handers may differ in sensory perceptions and respiratory responses to J receptor stimulation with intravenous injections of lobeline HCl in incremental doses. The comparison was made between 6 right handers and 9 left handers (all males) for
Early symptom-relief after valvulotomy in mitral stenosis indicates role of lobeline-sensitive intrapulmonary receptors.
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Respiratory sensations of eight patients with mitral stenosis in response to i.v. lobeline and 6-min walk before percutaneous mitral valvulotomy (PMV) were 'being short of breath', pressure in chest, tracheo-bronchial irritation, a desire to cough, persistent dry cough, chest pain and were
[A quantitative analysis of the phrenic nerve activities during the cough reflex].
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The phrenic nerve activity is an appropriate indicator for the output of the respiratory center as a whole, although a quantitative analysis of each of the frequency band components that constitute the neural activities during the respiratory reflex has not yet been made by other investigators. In
Role of vagal afferents in the reflex effects of capsaicin and lobeline in monkeys.
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Reflex effects of pulmonary C-fiber receptor stimulation by right atrial injections of capsaicin and lobeline were investigated in conscious monkeys (n=17). Capsaicin injection (15.0+/-1.4 microg/kg) produced apnea mostly (n=15, latency-1.7+/-0.2 s) and bradycardia, which were abolished by vagotomy
Afferent pathways for the cough reflex.
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Cough is most often a reflex act elicited by the stimulation of nervous receptors in the respiratory tract. The most important tussigenic areas are at the level of the larynx and the more distal portion of the trachea with its bifurcation. Laryngeal rapidly adapting receptors with myelinated fibres
Some recent advances in studies on J receptors.
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While describing recent advances in studies on J receptors it was shown that the discovery of the principle of the relative dilution of multiple solutes in flowing fluids paved the way for developing a new method for measuring in vivo the concentration of injected drugs in the blood of the pulmonary
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