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Nine diterpenoid alkaloids were isolated from the roots of ACONITUM BARBATUM VAR. PUBERULUM. Five of them are known: ranaconitine ( 1) [1], lappaconitine ( 2) [2], septentriodine ( 3) [3], septentrionine ( 4) [3], and lycaconitine ( 5) [4]. The other four are new: puberanine ( 6), puberanidine ( 7),
From the roots of Aconitum leave Royle growing wild in Northern Pakistan, Swat district, three new alkaloids, 8-methyllycaconitine (1), 14-demethyllycaconitine (2), N-deethyllycaconitine-N-aldehyde (3) have been isolated along with four known compounds, lappaconitine (4), lycaconitine (5),
To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB
In recent years recorded cases of plant poisoning have become rare, this may in part be due to the possibility of plant ingestion not being indicated at the beginning of an investigation. Aconitum napellus (aconite, Wolfsbane, Monkshood) is one of the most poisonous plants in the UK. It contains