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mesaconitine/artritis
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[Analgesic effects of Tsumura-shuuji-bushi-matsu and mesaconitine].
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"Tsumura-shuuji-bushi-matsu" (TJ-3021) is a herbal medicine produced from Aconiti tuber through autoclaving to decrease its toxicity. In this study, the analgesic effects of TJ-3021 and mesaconitine (MA) was examined in rats and mice. TJ-3021 (300 mg/kg, p.o.) or MA (0.5 mg/kg, p.o.) depressed the
Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy.
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BACKGROUND
Fuzi (lateral root of Aconitum carmichaeli) is a popular traditional Chinese medicine well known for its both therapeutic and high-toxic activities. Its toxic alkaloid ingredients, mainly aconitine, mesaconitine, and hypaconitine, are responsible for the high toxicity. However, to date,
Herb-induced aconitine poisoning presenting as tetraplegia.
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Both "chuanwu", the main root of Aconitum carmichaelii, and "caowu", the dried root of Aconitum kusnezoffii or other members of the Aconitum genus, have long been used in Oriental materia medica to treat rheumatism, arthritis, bruises, fractures and cardiac complaints. These herbs contain the highly
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