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myristica fragrans/anti alergi
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Bioactivities of Ethanolic Extracts of Three Parts (Wood, Nutmeg and Mace) from Myristica fragrans Houtt.
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Myristica fragrans Houtt. is one of the spices that has long been used for treatment of various disorders. M. fragrans is known as Chan-thet and its three parts i.e. wood, seed (nutmeg) and aril (mace), are ingredients in various Thai traditional remedies such as anti-pyretic, anti-allergy,
Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells.
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A methanol extract of mace, the aril of Myristica fragrans (Myristicaceae), was found to inhibit the release of β-hexosaminidase, a marker of antigen-IgE-stimulated degranulation in rat basophilic leukemia cells (RBL-2H3, IC50 = 45.7 μg/ml). From the extract, three new 8-O-4' type neolignans,
Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.
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Type I allergy is characterized by the release of granule-associated mediators, lipid-derived substances, cytokines, and chemokines by activated mast cells. To evaluate the anti-allergic effects of macelignan isolated from Myristica fragrans Houtt., we determined its ability to inhibit calcium
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