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Sigma (σ) receptor ligand, AC927 (N-phenethylpiperidine oxalate), attenuates methamphetamine-induced hyperthermia and serotonin damage in mice.
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Methamphetamine interacts with sigma (σ) receptors and AC927, a selective σ receptor ligand, protects against methamphetamine-induced dopaminergic neurotoxicity. In the present study, the effects of AC927 on methamphetamine-induced hyperthermia and striatal serotonergic neurotoxicity were evaluated.
Rapid, simple and sensitive microassay for skeletal muscle homogenates in the functional assessment of the Ca-release channel of sarcoplasmic reticulum: application to diagnosis of susceptibility to malignant hyperthermia.
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A microassay is demonstrated for functional characterization of the Ca(2+)-release channel (CRC) of sarcoplasmic reticulum (SR) of skeletal muscle using swine with susceptibility to malignant hyperthermia (MH). Diluted muscle homogenates, indo-1 and ratiometric dual-emission spectrofluorometry are
Unique Pediatric Gallstones Composed of Calcium Oxalate Phosphate
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Calcium oxalate phosphate is extremely rare composition of gall stones, with only one case reported in pediatric population till date. We report a case of pediatric cholelithiasis with a unique composition of calcium oxalate phosphate, detected at eight years of age. Its etiology remains unknown. An
Comparison of Ca++ uptake and spontaneous Ca++ release from sarcoplasmic reticulum vesicles isolated from muscle of malignant hyperthermia diagnostic patients.
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Inward Ca++ transport and spontaneous Ca++ release activities were compared among sarcoplasmic reticulum (SR) membrane fractions isolated from human skeletal muscle in patients undergoing malignant hyperthermia (MH) diagnostic contracture testing. Two different membrane fractions were isolated, a
Skeletal muscle sarcoplasmic reticulum in porcine malignant hyperthermia.
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To examine the function of sarcoplasmic reticulum (SR) in malignant hyperthermia, SR was isolated from semitendinosus muscle of normal and genetically susceptible Poland China swine. Determinations included rate of calcium binding (oxalate absent), rate and capacity of calcium uptake (oxalate
Oxalate nephropathy with a granulomatous lesion due to excessive intake of peanuts.
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A 65-year-old Japanese male developed renal dysfunction, showing proteinuria and marked urinary excretion of beta2-microglobulin. He had consumed approximately 100-200 g peanuts and 750-1,000 ml beer every day for two or three months. He had previously been treated for hypertension with an
Aspergillus niger pneumonia with fatal pulmonary oxalosis.
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Metabolic products of Aspergillus species may play a significant role in the pulmonary destructive process. We describe a patient who died of respiratory failure, in whom postmortem examination revealed aspergilloma and numerous calcium oxalate crystals around the aspergilloma, as well as extensive
Slow vs rapid delivery rate shock wave lithotripsy for pediatric renal urolithiasis: a prospective randomized study.
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OBJECTIVE
We compared slow vs fast shock wave frequency rates in disintegration of pediatric renal stones less than 20 mm.
METHODS
Our study included 60 children with solitary 10 to 20 mm radiopaque renal stones treated with shock wave lithotripsy. Patients were prospectively randomized into 2
Pharmacognostic studies on Pergularia daemia roots.
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Pergularia daemia (Forsk.) Chiov. (Asclepiadaceae) is used traditionally as an anthelmintic, laxative, antipyretic, and expectorant, and also used to treat malarial intermittent fever. But the scientific parameters are not yet available to identify the true plant material. In the present
Some observations on experimentally induced infection of dogs with Babesia gibsoni.
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Splenectomized andnonsplenectomized dogs were experimentally infected with Babesia gibsoni. Infectivity of parasites was retained for 1 month in samples of blood kept at 4 C in a mixture with Alsever's, acid-citrate-dextrose (ACD), or ammonium-potassium oxalate solutions. When samples were slowly
Severe, persisting, steroid-responsive Dengue myositis.
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OBJECTIVE
Short-term, general muscle affection is frequent in Dengue infection, but severe, persisting, myositis has not been reported.
METHODS
Case report.
RESULTS
The patient is a 38 years old, HIV-negative male who developed sudden-onset fever up to 40.0 degrees C, headache, and sore eyes upon
[Conservative therapy of phosphate calculi].
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Phosphate stones are divided in two groups: I. Infection stones = triple phosphate stones (struvite and carbonate apatite). II. Calcium phosphate stones = Hydroxy apatite. Ad I. For the formation of this stone, infection with urease-producing bacteria is essential. It is important to look for
[Essential phospholipids in the treatment of chronic pyelonephritis].
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The author's investigations led them to the conclusion that clinical manifestation of chronic pyelonephritis is associated with destabilization of lipid bilayer of red cell membranes, renal tissue, activation of lipid peroxidation (LPO), rising lipid and LPO products excretion with the urine. 31
[Renal colic and lithiasis in HIV(+)-patients treated with protease inhibitors].
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BACKGROUND
Protease inhibitors, mainly Indinavir, are widely used drugs for the treatment of patients infected by the human immunodeficiency virus (HIV) and are related to renal colic and urinary obstruction. These conditions are the result of urine excretion of these drugs which favours the
Evaluation of children with urolithiasis.
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OBJECTIVE
To describe an evaluation protocol for pediatric stone formers for risk assessment and management strategies.
METHODS
Between 2002-2006, 2618 children of age three months to 15 years were evaluated for stone disease. Evaluation included demographics, history, anthropometry, diet,
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