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psoriasis/sakit kepala
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Low-dose Naltrexone Therapy for Psoriasis.
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Safe, inexpensive, and convenient psoriasis therapy is desirable. Two recent case reports suggested that low-dose naltrexone is effective. Cases from our practice are presented in order to further the evidence of efficacy and safety of low-dose naltrexone in the treatment of psoriasis. Patients
Multiple sclerosis is associated with psoriasis. A case-control study.
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BACKGROUND
MS and psoriasis are both autoimmune diseases putatively mediated mainly by T cells.
OBJECTIVE
We conducted a case control study to investigate whether patients with MS have a high rate of comorbid psoriasis.
METHODS
The cohort consisted of 214 consecutive MS patients and a control group
Clinical effectiveness and safety experience with efalizumab in the treatment of patients with moderate-to-severe plaque psoriasis in Taiwan: results of an open-label, single-arm pilot study.
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BACKGROUND
No clinical trial of efalizumab has been conducted in Asia.
OBJECTIVE
To determine the efficacy and safety of efalizumab in Taiwanese patients with psoriasis.
METHODS
This is an open-label, single-arm pilot study conducted at two centres. Patients were given 1 mg/kg efalizumab
Clinical and histologic response to single-dose treatment of moderate to severe psoriasis with an anti-CD80 monoclonal antibody.
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Pathologic T-cell activation is implicated in psoriasis progression. CD80, a costimulatory molecule involved in T-cell activation, likely plays a key role. IDEC-114, an IgG(1) anti-CD80 antibody, was evaluated for safety, pharmacokinetics, and preliminary clinical activity in this open-label,
Efficacy and Safety of Apremilast in Patients With Moderate to Severe Plaque Psoriasis of the Scalp: Results of a Phase 3b, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study.
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Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis.
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BACKGROUND
CD11a/CD18 comprise subunits of leukocyte function associated antigen (LFA-1), a T-cell surface molecule important in T-cell activation, T-cell emigration into skin, and cytotoxic T-cell function.
OBJECTIVE
We explored the immunobiologic and clinical effects of treating moderate to severe
Efaluzimab in the treatment of psoriasis.
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We present a review of the literature concerning treatment of psoriasis with humanized monoclonal antibody (hu 1124, efaluzimab, Xanelin) against the CD11a component of lymphocyte-function-associated antigen-1 (LFA-1). Efaluzimab inhibits the interaction of CD11a (LFA-1) with various ICAM molecules.
Parenteral interferon-alpha treatment of psoriasis.
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12 patients suffering from psoriasis were given recombinant interferon (IFN)-alpha-2c at a daily dosage of 2.5 X 10(6) or 5 X 10(6) IU for up to 4 weeks by the intramuscular route. One patient showed complete regression and remained free of lesions after 12 months of follow-up. Three patients were
Generalized pustular psoriasis following withdrawal of efalizumab.
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Efalizumab is one of the new biologic therapies targeting T-lymphocyte activity for the treatment of chronic plaque psoriasis. Common adverse effects include headaches, nonspecific infection, nausea, chills, and fever. Rebound of psoriasis following discontinuation of the drug has been reported.
Improvement of Nail and Scalp Psoriasis Using Apremilast in Patients With Chronic Psoriasis: Phase 2b and 3, 52-Week Randomized, Placebo-Controlled Trial Results.
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BACKGROUND
A significant portion of patients with psoriasis have scalp and nail involvement. It has been reported that 40% to 45% of patients with psoriasis have nail psoriasis, and up to 80% have scalp involvement. Nail and scalp psoriasis have often been found to be difficult to treat, due to the
Etanercept and efalizumab for the treatment of psoriasis: a systematic review.
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OBJECTIVE
To evaluate the clinical effectiveness, safety, tolerability and cost-effectiveness of etanercept and efalizumab for the treatment of moderate to severe chronic plaque psoriasis.
METHODS
Major electronic databases and several Internet resources were searched up to April
Efficacy and safety of apremilast in subjects with moderate to severe plaque psoriasis: results from a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison study.
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BACKGROUND
Apremilast, a small molecule specific inhibitor of phosphodiesterase 4, works intracellularly to modulate pro-inflammatory and anti-inflammatory mediator production.
OBJECTIVE
Assess apremilast efficacy and safety in moderate to severe plaque psoriasis.
METHODS
Phase II, 12-week,
A Comparative Evaluation of Modined Goeckerman Regimen and Oral Psoralens Plus Phototherapy in Psoriasis.
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I Employing psoralen plus solar irradiation therapy in 20 patients with plaque psoriasis, improvement was noted in 55% of the patients. The overall improvement rate was however higher (95%) with coal tar plus solar irradiation treatment in the other group of 20 patients. In both groups, improvement
Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis.
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Fifty patients with chronic plaque psoriasis were treated with trioxsalen bath PUVA and 43 patients with oral methoxsalen PUVA. The two treatment regimens gave similar results; 75% and 77% of the patients had excellent or good clearing and a follow-up of one year revealed relapses in 61% and 58% of
Acupuncture as a Complementary Method of Traditional Psoriasis Treatment: Myth or Reality?
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Dear Editor, the practitioners of traditional Chinese medicine described psoriasis some 2000 years ago (1). Psoriasis vulgaris is a common, chronic inflammatory skin disease whose worldwide prevalence ranges from 0.1-3% (2,3). Understanding the role of the immune system in psoriasis and the
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