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11 hasil
Itacitinib in Advanced Hepatocellular Carcinoma
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JAKaL is a single arm phase Ib study evaluating the effect of Itacitinib in 25 patients with advanced HCC.
Many patients diagnosed with HCC will have advanced disease where only palliative care is offered to them, this could account for the relatively low reported 5-year survival rate of
Safety and Efficacy of Tofacitinib in the Treatment of NSAID Refractory Axial Spondyloarthritis:A Clinical Trial
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INTRODUCTION Spondyloarthritis (SpA) is one of the most prevalent forms of chronic inflammatory arthritis. It affects approximately 0.01-2.5% in the World wide. Estimated prevalence of SpA in India is between 0.1 to 0.2% and prevalence in Bangladesh is about 1.2% .
Janus kinase (JAK) is a family of
Androgenetic Alopecia and the JAK-STAT Pathway
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Background and rationale Androgenetic alopecia occurs in men and women,and is characterised by the loss of hair from the scalp in a defined pattern. Determining factors appear to be genetic predisposition coupled with the presence of sufficient circulating androgen.
The transformation of
Study of Icotinib Hydrochloride Cream in Patients With Mild to Moderate Psoriasis
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Icotinib Hydrochloride is an oral, small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which has been approved for treating advanced non-small cell lung cancer (NSCLC) in China. Over-expressions of EGFR and its downstream signaling proteins are implicated in the
The Effect of Urea Cream on Sorafenib-associated Hand-Foot Skin Reaction
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Sorafenib is multiple tyrosine kinase inhibitor. It blocks path that such as Raf-1, Vascular Endothelial Growth Factor Receptor (VEGFR), Platelet-Drived Growth Factor Receptor-β (PDGFR-β), c-Jit, Flt-3. Sorafenib was known to increase life rate about processed hepatocellular carcinoma. So it is
Cutaneous JAK in Vitiligo and Acne Vulgaris.
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The JAK/STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription. Binding of ligands, such as interferon and interleukins, to their specific transmembrane receptors activate associated JAKs. Phosphorylation of STAT follows, and
Icotinib Hydrochloride Cream in Patients With Mild to Moderate Psoriasis
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Icotinib Hydrochloride is a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which has been approved for the treatment of advanced nonsmall- cell lung cancer (NSCLC) in China in its oral form. As EGFR is implicated in the pathogenesis of psoriasis, icotinib
Icotinib Hydrochloride Cream in Healthy Adults and Psoriasis Patients
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Icotinib Hydrochloride is a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which has been approved for the treatment of advanced non-small-cell lung cancer (NSCLC) in China in its oral form. As EGFR is implicated in the pathogenesis of psoriasis, icotinib
A Phase 1 Study To Evaluate Tolerability, Safety, And Pharmacokinetics Of Topical PF-06263276 In Healthy Subjects
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Role of Tyrosine Kinase Lyn and Cleaved Form by Caspases in Psoriasis
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Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis
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Fractalkine (FKN), the sole member of the CX3C chemokine family, is named for its fractal geometry. The CX3C motif, with three amino acids between the two terminal cysteines, makes fractalkine distinct from other chemokines.The structure of fractalkine, a membrane-bound glycoprotein with the
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