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psorospermin/psorospermum febrifugum
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Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum.
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An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The
Antineoplastic agents from higher plants: application of tandem mass spectrometry to xanthones from Psorospermum febrifugum.
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Psorospermum febrifugum was examined using tandem ms for the presence of 3',4'-deoxypsorospermin-4'-chloro-3'-ol and psorospermin. Collision-induced dissociation at both high and low energy is used to bring about fragmentation. Daughter spectra were interpreted to reveal characteristic
Mechanism of action of the antileukemic xanthone psorospermin: DNA strand breaks, abasic sites, and protein-DNA cross-links.
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Psorospermin, a cytotoxic dihydrofuranoxanthone isolated from Psorospermum febrifugum, produced aberrant simian virus 40 DNA replication intermediates when added to lytically infected CV-1 monkey kidney cells. The aberrant viral intermediates showed dose-dependent DNA strand breaks and protein-DNA
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