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Circadian clocks and antiaging: do non-aging microalgae like Euglena reveal anything?
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Microalgae that divide symmetrically in all aspects do not age. While the evolutionary reason for this is obvious, little attention has been paid to the mechanistic explanations. A great deal of study involving many research fields would be needed to explain the mechanisms if we suppose that the
A Novel Matrikine-Like Micro-Protein Complex (MPC) Technology for Topical Skin Rejuvenation.
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This randomized, controlled, investigator-blinded study performed by an independent research organization evaluated the appearance of periorbital and perioral wrinkles following twice-daily application of a specific blend of matrikines and matrikine-like synthetic peptides for skin rejuvenation over
Toll-like receptor 7 agonists and skin.
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Toll-like receptor (TLR) 7 is an intracellular TLR that is expressed on membranes of endosomes and recognizes nucleosides and nucleotides from intracellular pathogens. Synthetic agonists of TLR7 comprise guanine nucleoside analogues, stabilized immune modulatory RNA, as well as
Absolute Configuration of Mycosporine-Like Amino Acids, Their Wound Healing Properties and In Vitro Anti-Aging Effects.
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Mycosporine-like amino acids (MAAs) are water-soluble metabolites, reported to exhibit strong UV-absorbing properties. They have been found in a wide range of marine organisms, especially those that are exposed to extreme levels of sunlight, to protect them against solar radiation. In the present
Reversibility of cellular aging by reprogramming through an embryonic-like state: a new paradigm for human cell rejuvenation.
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Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential application in autologous tissue replacement therapies and without the ethical concerns of Embryonic Stem Cells (hESC). However, this
Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects.
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OBJECTIVE
The study was undertaken to compare the skin care related activities of retinol and bakuchiol, a potential alternative to retinoids. Retinol is a pivotal regulator of differentiation and growth of developing as well as adult skin. Retinoic acid is the major physiologically active
Antiaging Factor Klotho Retards the Progress of Intervertebral Disc Degeneration through the Toll-Like Receptor 4-NF-κB Pathway.
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Antiaging protein Klotho exhibits impressive properties of anti-inflammation, however is declined early after intervertebral disc injury, making Klotho restoration an attractive strategy of treating intervertebral disc inflammatory disorders. Here, we have found that Klotho is enriched in nucleus
Very small embryonic-like (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity.
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Recently, we purified rare CXC chemokine receptor 4 expressing (CXCR4(+)) small stem cells (SCs) from the murine bone marrow (BM) that express markers characteristic for embryonic (E)SCs, epiblast (EP)SCs, and primordial germ cells (PGCs). We named these primitive cells very small embryonic-like
Farnesol-like endogenous sesquiterpenoids in vertebrates: the probable but overlooked functional "inbrome" anti-aging counterpart of juvenile hormone of insects?
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Literature on the question whether the juvenile stage of vertebrates is hormonally regulated is scarce. It seems to be intuitively assumed that this stage of development is automated, and does not require any specific hormone(s). Such reasoning mimics the state of affairs in insects until it was
Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation.
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Thymic involution is associated with age-related changes of the immune system. Utilizing our innovative technique of transplantation of a thymus as an isolated vascularized graft in MHC-inbred miniature swine, we have previously demonstrated that aged thymi are rejuvenated after transplantation into
Antioxidative, Anti-Inflammatory, and Anti-Aging Properties of Mycosporine-Like Amino Acids: Molecular and Cellular Mechanisms in the Protection of Skin-Aging.
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Prolonged exposure to ultraviolet (UV) radiation causes photoaging of the skin and induces a number of disorders, including sunburn, fine and coarse wrinkles, and skin cancer risk. Therefore, the application of sunscreen has gained much attention to reduce the harmful effects of UV irradiation on
Is insulin-like growth factor-1 involved in Parkinson's disease development?
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Parkinson's disease (PD) is a neurodegenerative disorder that results in the death of dopaminergic neurons within the substantia nigra pars compacta and the reduction in dopaminergic control over striatal output neurons, leading to a movement disorder most commonly characterized by akinesia or
[The physiological role of growth hormone and insulin-like growth factors].
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The existence of insulin-like growth factors (IGFs) was recognized in connection with the stimulation of sulfate incorporation into cartilage. IGFs take part in the embryonal development and postnatal growth, in interaction with the growth hormone (GH). The physiological effects of IGF1 are
Enumeration of very small embryonic-like stem cells in peripheral blood.
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In addition to hematopoietic stem and progenitor cells (HSPCs) also other types of stem cells (e.g., -mesenchymal stem cells [MSCs], endothelial progenitor cells [EPCs], and very small embryonic-like stem cells [VSELs]) circulate under steady-state conditions at detectable levels in peripheral blood
Overexpression of DnaJ-Like Chaperone Enhances Carotenoid Synthesis in Chlamydomonas reinhardtii.
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Production of functional carotenoids using microalgae may facilitate the commercialization of anti-aging nutritional supplements. The green alga Chlamydomonas reinhardtii uses a non-mevalonate (MEP) pathway for isopentenyl diphosphate (IPP) synthesis. Two enzymes thought to play important roles in
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