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Procedural sedation is a common practice in Emergency Medicine. Propofol has supplanted benzodiazepines in many centers as the drug of choice for procedural sedation. This article reports a case of seizure-like activity in an elderly man undergoing procedural sedation for a fracture reduction. The
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I will describe experiments with neurons in long-term culture that display seizure-like electrical activity. The neurons are dissociated from the hippocampal formation of newborn rats and then chronically exposed to agents that block synaptic transmission, especially glutamatergic transmission.
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Much debate exists about how the brain transitions into an epileptic seizure. One source of confusion is that there are likely to be critical differences between experimental seizure models. To address this, we have compared the evolving activity patterns in two widely used in vitro models of
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Oxytocin (OT) and arginine-vasopressin (AVP) are involved in the physiological response to different stressors like the occurrence of seizures which is regarded as a severe stress factor. Zebrafish (Danio rerio) is recently featured as a model of epilepsy but the role of neurohypophyseal hormones on
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Following the withdrawal of methohexitone from the market place psychiatrists and anaesthetists have been forced to seek out alternative anaesthetic agents for ECT. We report a case of etomidate-induced seizure-like activity. We review the literature on ECT and anaesthetic agents and discuss the
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Generalized clonic and tonic seizure-like movements were observed during emergence from anesthesia with sevoflurane in a 32-year-old man. The movements lasted 40 sec and necessitated no therapy. There were no significant effects of the incident on the cardiovascular system, such as hypotension,
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Amnesia is one of the most common consequences of seizures. We modelled this phenomenon in the in vitro hippocampal slice preparation by examining effects of seizure-like activity on long-term potentiation (LTP). LTP is an expression of neuronal plasticity which has been correlated with learning.
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Neuronal circuits exhibiting seizure episodes have been shown to be prone to multistability. The coexistence of normal and pathological regimes could explain why seizures suddenly start and stop. Methods developed in dynamical systems theory are powerful tools for determining the cellular mechanisms
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