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silybinin/lamyropsis microcephala
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Extraction of nutraceuticals from milk thistle: I. Hot water extraction.
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Milk thistle contains compounds that display hepatoxic protection properties. We examined the batch extraction of silymarin compounds from milk thistle seed meal in 50, 70, 85, and 100 degrees C water as a function of time. After 210 min of extraction at 100 degrees C, the yield of taxifolin was 1.2
Extraction of nutraceuticals from milk thistle: part II. Extraction with organic solvents.
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Seeds from milk thistle (Silybum marianum Gaert L.) contain flavanolignan and dihydroflavanol compounds that have interesting and important therapeutic activities. The recovery of these silymarin compounds generally involves a two-step defatting and extraction process using organic solvents. This
Pretreatment of milk thistle seed to increase the silymarin yield: an alternative to petroleum ether defatting.
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Milk thistle (Silybum marianum L.) seed meal is extracted for the flavonolignans, silychristin, silydianin, silybinin A, silybinin B, isosilybinin A and isosilybinin B, which are collectively known as the silymarin complex. To obtain the flavonolignans, the meal is usually treated with successive
Batch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. Gaertner).
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Seeds of milk thistle (Silybum marianum L. Gaertner) contain silymarins and ca. 25% (w/w) of oil. A pre-treatment step involving refluxing with petroleum ether is usually performed before extraction of the silymarins using organic solvents. This paper compares the extraction of whole and defatted
Supercritical CO₂ extraction of oil, fatty acids and flavonolignans from milk thistle seeds: Evaluation of their antioxidant and cytotoxic activities in Caco-2 cells.
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The optimal conditions of supercritical carbon dioxide (SC-CO2) (160-220 bars, 40-80 °C) technology combined with co-solvent (ethanol), to recover oil, flavonolignans (silychristin, silydianin and silybinin) and fatty acids from milk thistle seeds, to be used as food additives and/or nutraceuticals,
Modern phytotherapy and its uses in gastrointestinal conditions.
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A discussion of the historical background, development, and legal and philosophical aspects of phytotherapy as well as suggestions for its scientific basis is presented. Applications of phytotherapy for various gastrointestinal conditions are discussed for the examples of three remedies. The first
Modern phytotherapy and its uses in gastrointestinal conditions.
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A discussion of the historical background, development, and legal and philosophical aspects of phytotherapy as well as suggestions for its scientific basis is presented. Applications of phytotherapy for various gastrointestinal conditions are discussed for the examples of three remedies. The first
Selective Synthesis of 3-O-Palmitoyl-Silybin, a New-to-Nature Flavonolignan with Increased Protective Action against Oxidative Damages in Lipophilic Media.
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A selective acylation protocol using cerium chloride (CeCl₃) as catalyst was applied to functionalize silybinin (1), a natural antioxidant flavonolignan from milk thistle fruit, in order to increase its solubility in lipophilic media while retaining its strong antioxidant activity. The selective
Antifibrogenic therapies in chronic HCV infection.
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The most common cause of hepatic fibrosis is currently chronic HCV infection, the characteristic feature of which is hepatic steatosis. Hepatic steatosis leads to an increase in lipid peroxidation in hepatocytes, which in turn activates hepatic stellate cells (HSCs). HSCs are also regarded as the
[Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride].
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An oil obtained from the seeds of Saint-Mary thistle (Silybum marianum) and the drug legalon (silybinin) prepared from this plant produce an antioxidant effect on liver tissues of rats poisoned with carbon tetrachloride. Legalon (25 mg/kg) and the oil (2000 mg) reduced the level of lipid
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