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sophora microphylla/hypoxia
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[Effect of total alkaloids of kudouzi (Sophora alopecuroides L.) on tolerance to anoxia in mice].
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To several anoxia mice models, total alkaloids of Kudouzi (TASa) can prolong their tolerance time (ip < 1/10, 1/5LD50/kg, P < 0.05-0.01). In the experiment of myocardial ischemia induced by pituitrin, TASa decreased significantly the ST change in ECG (P < 0.05). The acute LD50 of TASa by ip was
Oxymatrine prevents hypoxia- and monocrotaline-induced pulmonary hypertension in rats.
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Pulmonary hypertension is a progressive disease characterized by marked pulmonary arterial remodeling and increased vascular resistance. Inflammation and oxidative stress promote the development of pulmonary hypertension. Oxymatrine, one of the main active components of the Chinese herb Sophora
Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death.
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Oxymatrine (OMT), an active constituent of Chinese herb Sophora flavescens Ait, has been proved to possess anti-tumor, anti-oxidant, anti-inflammatory, and anti-apoptotic activities. Previous study has demonstrated that OMT had protective roles on multiple in vitro and in vivo brain injury models
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