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Stemoninines from the roots of Stemona tuberosa.

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Five new stemoninine-type alkaloids, bisdehydrostemoninine (1), isobisdehydrostemoninine (2), bisdehydroneostemoninine (3), and bisdehydrostemoninines A (4) and B (5), were isolated from the crude-alkaloid extract of the roots of Stemona tuberosa. Their structures were elucidated on the basis of

Antitussive stemoninine alkaloids from the roots of Stemona tuberosa.

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Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a- O-methylstemoenonine (2), oxystemoenonine (3), 1,9a- seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D

Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa.

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The intestinal absorption of four stereoisomers of tuberostemonine-type alkaloids, neotuberostemonine (1), tuberostemonine (2), tuberostemonine H (3), and tuberostemonine J (4), isolated from the antitussive Chinese medicinal herb Radix Stemonae, and the IN VIVO antitussive activity of alkaloids 1,

Antitussive activity of Stemona alkaloids from Stemona tuberosa.

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Bioactivity-directed fractionation of the crude extract of Stemona tuberosa led to the isolation and characterization of four new stenine-type Stemona alkaloids, namely tuberostemonine J ( 2), tuberostemonine H ( 3), epi-bisdehydrotuberostemonine J ( 4) and neostenine ( 5), together with the known

[Comparative study of four alkaloids contents and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province].

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OBJECTIVE To compare the contents of four alkaloids and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province. METHODS The HPLC separation was performed on a Merck Purospher STAR RP18 (250 mm x 4. 6 mm, 5 µm) column by gradient elution using 0. 05%

Antitussive and central respiratory depressant effects of Stemona tuberosa.

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OBJECTIVE Stemona alkaloids with distinctly different chemical skeletons are recently reported as the active components in the antitussive herb Baibu derived from the root-tubers of Stemona tuberosa. This study aims to determine if alkaloids of this herb contribute equally to the antitussive

[Difference in effect between asthma-based mouse model and Stemona tuberosa extracts].

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In this study, OVA-induced asthma mice was taken as the model, and orally administered with different concentration of ethanol extracts of crude and processed Stemona tuberosa, in order to determine the cytokine level released from Th1 and Th2 in splenocytes. RT-PCR was carried out to determine the

Alkaloids from roots of Stemona sessilifolia and their antitussive activities.

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Protostemonamide ( 1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine ( 2), stemospironine

The traditional uses, phytochemistry, and pharmacology of Stemona species: A review

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Ethnopharmacological relevance: Plants of genus Stemona (Stemonaceae) have long been used locally and traditionally in many South and East Asia counties to relieve cough, dispel phlegm, prevent asthma, control pests, diminish inflammation

Structural relationships, distribution and biological activities of stemona alkaloids.

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Stemona alkaloids represent a unique class of natural products exclusively isolated from the monocotyledonous family Stemonaceae comprising three genera mainly distributed in southeast Asia. Structurally the alkaloids are characterised by a pyrrolo[1,2- a]azepine nucleus usually linked with two

[Antitussive activity comparison of three kinds of Stemonae Radix in Chinese Pharmacopoeia].

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OBJECTIVE To compare the antitussive activity of three kinds of Stemonae Radix specified in the Chinese Pharmacopoeia, including roots of Stemona sessilifolia, S. japonica and S. tuberosa. METHODS The antitussive activity was determined in mouse after cough induction by ammonia aerosol stimulation

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