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stevioside/atrofi
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A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension.
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OBJECTIVE
Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the
Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species.
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The acute toxicity of stevioside and steviol (a product of enzymatic hydrolysis of stevioside) was investigated in three animal species including rat, mouse and hamster. The susceptibility to stevioside and steviol acute toxicity in both sexes of these animal species was compared. The animals were
Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation.
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Overexpression of aquaporin 2 (AQP2) was observed and suggested to be involved in fluid secretion leading to cyst enlargement in polycystic kidney disease (PKD). The cyst expansion deteriorates the renal function and, therefore, therapies targeting cyst enlargement are of clinical interest. Of note,
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