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It was shown in experiments on rats with experimental ischemic myocardial infarction that strophanthin inhibits free-radical lipid peroxidation, decreases (in mean and little doses) the ectopic activity of the myocardium, eliminates tachyarrhythmias arising in the presence of coronary occlusion,
A study was made of strophanthin sensitivity and hemodynamic effect of glycosidein immunization of rabbits with a homocardiac antigen on the 1st, 3rd and 5th days after the reproduction of myocardial infarction. The titre of anticardiac autoantibodies proved to decrease on the 10th day after the
The tolerance to strophanthin was studied in acute and subacute experiments on 76 cats at varying time after occlusion of the coronary artery branch. The beta-adrenoblocker alpheprol completely smoothed away the hypersensitivity to strophanthin after the coronary blood flow cessation while the
The effects of isolated and combined use of strophanthin and glucagon on the values of central hemodynamics and cardiac contractile function were compared. The study was conducted on patients with myocardial infarction complicated by congestive heart failure in the acute period of the disease. It
The tolerance changes to strophanthin in cats were studied during 7 days after occlusion of the coronary artery along with the determination of the electrolyte concentration in different areas of the myocardium. It is shown that the acute disorder of the coronary circulation produces during 2 days
The effect of a series of drugs (retabolil, strophanthin, retabolil with strophanthin, retabolil with panangin , methyluracil with panangin ) on protein metabolism was investigated in 246 patients with acute myocardial infarction. Retabolil both alone and combined with panangin , and a
The effect of single therapeutic doses of strophanthin (0.25--0.4 mg) and atropine (0.75--1,0 mg) on cardiac contraction was studied in 39 patients with acute myocardial infarction and in 12 subjects with no signs of organic heart affection by recording the electrical potentials of the heart
The results of a complex study are presented dealing with the effect of Strophantin on metabolism, electrolytes content, myocardial ultrastructure and contractile function of various portions of the heart in dogs with experimentally induced infarction. Under the effect of Strophantin the destructive
The results of clinical and instrumental examination of 67 patients and experimental findings provide evidence of myocardial resistance to cardiac glycosides in acute myocardial infarction complicated by the initial stage of cardiac insufficiency. It is suggested that symptoms of secondary