Potassium citrate x 7days Off therapy x 7 days 500 mL low calorie orange juice beverage x 7 days 1000 mL low calorie orange juice beverage x 7 days Return to potassium citrate therapy Litholink urine collection to be performed after each 7 days treatment

500 mL low calorie orange juice beverage x 7 days 1000 mL low calorie orange juice beverage x 7 days Off therapy x 7 days Potassium citrate x 7days Continue on potassium citrate therapy Litholink urine collection to be performed after each 7 days treatment

Kidney Calculi

Kroger low calorie orange juice beverage will be consumed for 7 days followed by a 24 hour urine collection with Litholink to see if urine alkalization similar to potassium citrate can be achieved

Kroger low calorie orange juice beverage

Indiana University Health Methodist Hospital

Indiana University Health Physicians Urology

A Dietary Source of Potassium Citrate to Resolve Hypocitraturia and Aciduria in Patients With Kidney Stones

A Dietary Source of Potassium Citrate to Resolve Hypocitraturia and Aciduria in Patients With a History of Nephrolithiasis

The primary endpoint of interest will be the changes in urinary citrate while consuming Kroger low calorie orange juice beverage compared to potassium citrate therapy.

The primary endpoint of interest will be the changes in urinary pH while consuming Kroger low calorie orange juice beverage compared to potassium citrate therapy.

Tim Large

Principal Investigator

Indiana University

Group 1 kcit x 7 days ↓ Litholink on day 7
↓ off therapy x 7 days
↓ OJ 500 ML + 1.5L water /day x 7 days
↓ Litholink on day 7
↓ OJ 1000 ML + 1L water /day x 7 days
↓ Litholink on day 7 Return to kcit therapy
Group 2 OJ 500 ML + 1.5L water /day x 7 days ↓ Litholink on day 7
↓ OJ 1000 ML + 1L water /day x 7 days
↓ Litholink on day 7
↓ off therapy x 7 days
↓ kcit x 7 days
↓ Litholink on day 7 Continue on kcit therapy

Participants will undergo one day of habitual eating followed by 36 hours of water only fasting and final day of habitual eating of the exact same diet consumed on the first eating day. Blood draws will be performed on Day 1 in a 10-12 hr fasted state and 2 hour postprandial state and again on Day 3 in a 36hr fasted state and a 2 hour post prandial state. Microbiome samples and blood glucose data will be collected throughout the course of the study.

Fasting

Participants will undergo one day of habitual eating followed by 36 hours of water-only fasting and final day of habitual eating consuming the exact same diet consumed on the first eating day. Blood draws will be performed on Day 1 in a 10-12 hr fasted state and 2 hour postprandial state and again on Day 3 in a 36hr fasted state and a 2 hour post prandial state. Microbiome samples and blood glucose data will be collected throughout the course of the study.

University of California Davis

Effects of Prolonged Fasting on Microbiome and HDL

The Effects of Prolonged Fasting on the Microbiome and HDL Particles of Human Subjects

HDL will be isolated from plasma samples and HDL immunomodulatory capacity will be assessed in isolated HDL with an in vitro assay using stimulated macrophages.

Gut microbial composition will be assessed by sequencing of isolated DNA from stool samples.

sweeteners/sakit kepala

A Dietary Source of Potassium Citrate to Resolve Hypocitraturia and Aciduria in Patients With Kidney Stones

Effects of Prolonged Fasting on Microbiome and HDL

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