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tenuifolin/polygala
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Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice.
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BACKGROUND
Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities.
Protective effects of tenuifolin isolated from Polygala tenuifolia Willd roots on neuronal apoptosis and learning and memory deficits in mice with Alzheimer's disease.
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The roots of Polygala tenuifolia Willd have a long history of being used as a traditional Chinese medicine for the treatment of insomnia, forgetfulness, sorrow and depression. Tenuifolin (TEN) has been isolated from Polygala tenuifolia Willd roots, and this study was carried out to investigate the
Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.
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OBJECTIVE
Previous studies have shown that tenuigenin, a crude extract of Polygala tenuifolia Willd. that is commonly used in traditional Chinese herbal medicine for memory loss, can reduce the secretion of Abeta from cultured cells. However, the mechanism underlying this effect and the active
Tenuifolin Attenuates Amyloid-β42-Induced Neuroinflammation in Microglia Through the NF-κB Signaling Pathway
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Background: Inflammation and oxidative stress are believed to play an important role in the pathogenesis of Alzheimer's disease (AD). Tenuifolin (TEN) is a natural neuroprotective compound extracted from Polygala tenuifolia Willd, which
Polygala tenuifolia: a source for anti-Alzheimer's disease drugs
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Context: Alzheimer's disease (AD) is a chronic neurodegenerative disease that originates from central nervous system lesions or recessions. Current estimates suggest that this disease affects over 35 million people worldwide. However, lacking effective drugs is the biggest handicap in
[HPLC Fingerprint and Active Components Determination of Polygala tenuifolia Root Bark and Root].
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OBJECTIVE
To compare the difference between Polygala tenuifolia root bark and root using HPLC fingerprint analysis and active components determination.
METHODS
Three main characteristic components including tenuifolin, polygalaxanthone III, and 3, 6'-disinapoly sucrose in different Polygala
[Rationality of commodity criteria and traditional breeding of Polygala tenuifolia based on agronomic traits and determination of chemical components].
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The agronomic traits (plant height, root diameter, root length, first lateral root height, lateral root amount, root weight) of 18 Polygala tenuifolia samples with different agronomic traits were analyzed, respectively. HPLC was used to analyze three main characteristic components including
Chemical investigation of the roots of Polygala sibirica L.
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OBJECTIVE
To investigate the chemical constituents of the roots of Polygala sibirica L. (Polygalaceae)
METHODS
The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical
Anti-angiogenic effect of triterpenoidal saponins from Polygala senega.
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Senegasaponins [senegin II (1), senegin III (2), senegin IV (3), senegasaponin a (4), and senegasaponin b (5)] from Polygala senega were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs). Senegasaponins (1-5) showed anti-proliferative
[Intestinal Absorption Characteristics and Mechanism of Polygala tenuifolia Hydrolysate in Rats].
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OBJECTIVE
To evaluate the absorption feature and mechanism of tenuifolin(TF) and polygalaxanthone III (PT) in different intestinal parts of rats and the impact of MRP2 and P-glycoprotein (P-gp) on it.
METHODS
In situ unidirectional perfusion was used to detect the concentration of TF and PT through
An LC-MS/MS method for simultaneous determination of three Polygala saponin hydrolysates in rat plasma and its application to a pharmacokinetic study.
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BACKGROUND
Radix Polygala has a long history of use as a sedative in traditional Chinese medicine and its major ingredients are saponins, which are recognized effective in memory improvement but highly toxic to gastricintestinal mucosa. Polygala saponin hydrolysates (PSH), an alkaline hydrolysis
The gastrointestinal irritation of polygala saponins and its potential mechanism in vitro and in vivo.
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Processing alters the pharmacological activity and reduces the gastrointestinal toxicity of the polygalae. To investigate the effect of processing, different glycosyl substituent products were tested. Hypnotic and subhypnotic doses of pentobarbital-induced sleep tests on mice were used to evaluate
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