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tenuigenin/amiloidosis
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[Protective effect of tenuigenin on cytotoxicity of primary cultures of cortical neurons induced by amyloid beta-protein 1-40 (Abeta(1-40))].
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OBJECTIVE
To observe the effect of tenuigenin (TEN) on aggregated amyloid beta-protein 1-40 (Abeta(1-40)-induced cytotoxicity of primary cultural cortical neurons in vitro.
METHODS
In order to establish neurotoxic model, the primary cultural rat cortical neurons were treated with 25 micromol x L(-1)
Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells.
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Amyloid beta-protein (A beta) is a pivotal pathological factor in Alzheimer's disease (AD). Tenuigenin, extracted from the Chinese herb Polygala tenuifolia, seems to ameliorate the reduction in cholinergic function on rat models induced by A beta. To examine this therapeutic effect, we tested
Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.
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OBJECTIVE
Previous studies have shown that tenuigenin, a crude extract of Polygala tenuifolia Willd. that is commonly used in traditional Chinese herbal medicine for memory loss, can reduce the secretion of Abeta from cultured cells. However, the mechanism underlying this effect and the active
[The mechanism of tenuigenin for eliminating waste product accumulation in cerebral neurons of Alzheimer's disease rats via ubiquitin-proteasome pathway].
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OBJECTIVE
To explore the scavenging action of tenuigenin (TEN) on intracerebral amyloid β protein (Aβ) aggregation and the abnormal phosphorylated tau protein and its mechanism in Alzheimer's disease (AD) rats' brain.
METHODS
Aβ1-40 was injected into the right CA1 region hippocampus to establish the
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