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Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.
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Inhalation of Bacillus anthracis spores can cause a rapidly progressing fatal infection. B. anthracis secretes three protein toxins: lethal factor (LF), edema factor (EF), and protective antigen (PA). EF and LF may circulate as free or PA-bound forms. Both free EF (EF) and PA-bound-EF (ETx) have
[Acute adrenalin pulmonary edema in non-pregnant animals treated with blood serum of pregnant women with toxemia].
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Experimental edema disease (hemolytic Escherichia coli toxemia) in pigs and in mice.
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PLACENTAL MORPHOLOGY IN PATHOLOGIC GESTATIONS WITH OR WITHOUT TOXEMIA. OBSERVATIONS IN CASES OF DIABETES MELLITUS, HYDROPS FETALIS, TWIN PREGNANCY, PLACENTA PREVIA, AND HYDATIDIFORM MOLE.
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[Edema formation in late pregnancy toxemias with special consideration of the acid mucopolysaccharides].
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[The importance of histamine for edema formation in late toxemia of pregnancy].
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Causes of edema in the intensive care unit.
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Patients in emergencies necessitating treatment in the intensive care unit (ICU) often develop generalized gross edema. The usual scenario is that in the emergency situation characterized by hypotension and (impending) organ failure, large amounts of fluids are administered that subsequently cannot
[Effect of pancreatic kallikrein and trypsin inhibitors on the course of postischemic toxemia].
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By studying the ECG findings, dynamic changes of the body temperature, the edemas size in the tourniquet-compressed limbs, vascular permeability of the skin, general condition and survival rate on a model of post-ischemic toxemia in albino rats it was found that the serum containing antibodies to
Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis.
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Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax disease in humans and animals. Systemic infection is characterized by septicemia, toxemia, and meningitis, the main neurological complication associated with high mortality. We have shown previously that B. anthracis
Femtomolar detection of the anthrax edema factor in human and animal plasma.
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Edema factor (EF), a calmodulin-activated adenylyl cyclase, is a toxin which contributes to cutaneous and systemic anthrax. As a novel strategy to detect anthrax toxins in humans or animals infected by Bacillus anthracis, we have developed a sensitive enzymatic assay to be able to monitor functional
Edema and tetraparesis in a miniature pig after allogeneic hematopoietic cell transplantation.
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A 3-mo-old, 12-kg, intact, miniature pig presented with severe neurologic signs on day 8 after hematopoietic cell transplantation. This pig had received an immunosuppressive regimen before transplantation that included an antiCD3 immunotoxin for T-cell depletion, 100 cGy of total-body irradiation,
ANTIDIURETIC PITUITARY SUBSTANCE IN BLOOD, WITH SPECIAL REFERENCE TO THE TOXEMIA OF PREGNANCY.
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A method is described for the quantitative extraction of posterior pituitary antidiuretic substance from blood with which it has been mixed in vitro and in vivo for experimental purposes. With this procedure, it is found that a similarly extractable active substance may be detected as a normal
An experimental study on "replantation toxemia". The effect of hypothermia on an amputated limb.
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Hind legs of dogs were amputated at the middle of the thigh and preserved in three different conditions: in ice water, in a refrigerator, and at room temperature. After 6 or 12 hours of ischemia, recirculation was established. The survival rate of the animals was observed and measurement of limb
Shiga toxin 2eB-transgenic lettuce vaccine is effective in protecting weaned piglets from edema disease caused by Shiga toxin-producing Escherichia coli infection.
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Porcine edema disease (ED) is a toxemia that is caused by enteric infection with Shiga toxin 2e (Stx2e)-producing Escherichia coli (STEC) and is associated with high mortality. Since ED occurs most frequently during the weaning period, preweaning vaccination of newborn piglets is required. We
Anthrax edema toxin impairs clearance in mice.
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The anthrax edema toxin (ET) of Bacillus anthracis is composed of the receptor-binding component protective antigen (PA) and of the adenylyl cyclase catalytic moiety, edema factor (EF). Uptake of ET into cells raises intracellular concentrations of the secondary messenger cyclic AMP, thereby
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