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[Antiulcer effects of the tripeptide PGP and its possible metabolites (PG, GP, glycine, and proline) in different models of ulcer induction in rats].
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The study of the effect of equimolar concentrations (3.7 micromol/kg) of the tripeptide PGP and its possible metabolites--PG, GP, proline, and glycine--on ethanol-, stress-, and indomethacin-induced ulcer development in rats showed that only PGP exhibited consistent antiulcer effects on all three
Prolidase deficiency: the use of topical proline for treatment of leg ulcers.
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A 41-year-old man with prolidase deficiency has had chronic leg ulcers and recurrent cellulitis for most of his life. Until recently he had been hospitalized at least annually for this and suffered significant morbidity as a result. Since commencing topical 5% proline in white soft paraffin ointment
[Effective therapy with a glycine-proline ointment in a patient with recurrent ulcers from prolidase deficiency].
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BACKGROUND
Prolidase deficiency is a rare disease. Lower leg recalcitrant ulcerations are the most characteristic symptoms.
METHODS
Woman diagnosed of prolidase deficiency with leg recalcitrant and infected ulcerations. Dermatology service solicits a proline and glycline containing ointment after
[Correction of the stomach blood flow as a mechanism of anti-ulcer effects of short proline-containing peptides].
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Intraperitoneal administration of the PGP did not change basal mucosal blood flow, whereas the PG and GP significantly decreased it. Ethanol and Indomethacin caused a rapid and stable decrease in the blood flow. Administration of the PGP prior to ethanol abolished this effect. Injections of the PGP
Effect of topical application of glycine and proline on recalcitrant leg ulcers of prolidase deficiency.
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Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model.
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The roles of polypeptide growth factors in promoting wound healing and in directing the specificity and sequence of responses of different tissues in wounds are little understood. We investigated the influence of four growth factors on the rates of healing of a novel full thickness dermal ulcer
Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing.
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Fibroblasts (FIB) play an important role in the wound-healing process. It is not known whether human skin and gastric FIB show different responses to regulatory compounds. In this study, we have examined the collagen production by these FIB after different stimuli. In vitro release of collagen into
Purification of Helicobacter pylori NCTC 11637 cytochrome bc1 and respiration with D-proline as a substrate.
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Helicobacter pylori is a microaerophilic bacterium associated with gastric inflammation and peptic ulcers. Knowledge of how pathogenic organisms produce energy is important from a therapeutic point of view. We found d-amino acid dehydrogenase-mediated electron transport from d-proline or d-alanine
Accelerated healing of ulcer wounds in the rabbit ear by recombinant human transforming growth factor-beta 1.
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A dermal ulcer wound-healing model was established in rabbit ear to examine the effects of recombinant human transforming growth factor-beta 1 (rhTGF-beta 1) in wound healing. Histomorphometric examination of the wounds indicate a biphasic healing response 7 days after a single application of
Proline is not useful as a chemical probe to measure nitrosation in the gastrointestinal tract of patients with gastric disorders characterised by anacidic conditions.
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Aspirated fasting gastric juice from patients with lesions of the gastrointestinal tract and from healthy controls was analysed for nitrite before and after (30, 90, and 240 min) oral administration of 200 mg nitrate. Wilcoxon's rank-sum tests showed no significant differences in fasting gastric
Arginine metabolites in wound fluids from pressure ulcers: a pilot study.
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Compelling evidence suggests that nitric oxide (NO*), a metabolite of arginine, plays an important role in wound healing. Arginine is a semi-essential amino acid that is metabolized by nitric oxide synthase and arginase. One model for wound-healing regulation suggests the importance of strict
Dermal fibroblasts from venous ulcers are unresponsive to the action of transforming growth factor-beta 1.
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Failure to reepithelialize is the major clinical problem in venous ulcers. It is not clear whether the problem resides with keratinocytes or with inadequate and improper formation of extracellular matrix. In this study, we characterized the biosynthetic activity and response to transforming growth
35S and 3H-proline incorporation in rats deficient in essential fatty acids.
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The effects of essential fatty acid (EFA) deficiency on connective tissue metabolism were studied in rats deficient in EFA and prostaglandins (PG). In chronic EFA deficiency, 3H-proline fixation, a measure of protein synthesis, was markedly reduced in the stomach, liver, adrenal, kidney, spleen,
[The amino acid composition of the blood serum and gastric mucosa in peptic ulcer with involvement of the hepatobiliary system and intestines in patients of different ages (1)].
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Disaminoacidemia was shown to be of much higher degree in involvement of the intestinal hepatobiliary system in patients with ulcer disease, in addition, in elderly and old people the content of free amino acids (AA) in the blood serum is significantly reduced. Present in the least amounts are
NMR conformational analysis of cis and trans proline isomers in the neutrophil chemoattractant, N-acetyl-proline-glycine-proline.
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Alkaline hydrolysis of corneal proteins in the alkali-injured eye releases N-acetyl-proline-glycine-proline (Ac-Pro-Gly-Pro-OH) among other peptides. It has been shown that this tripeptide is a neutrophil chemoattractant. Existing data suggest that the release of this peptide is the catalytic event
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