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NTP Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CAS No. 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
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C.I. Acid Orange 3 is a dinitrodiphenylamine derivative used exclusively as a dye (up to 0.2%) in semipermanent hair coloring products. This study was one of a series on semipermanent hair dyes, which included HC Blue No. 1 (NTP TR 271), HC Blue No. 2 (NTP TR 293), HC Red No. 3 (NTP TR 281), and
Elevated bone turnover in rat polycystic kidney disease is not due to prostaglandin E2.
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Hyperparathyroidism, secondary to renal disease, is thought to cause high bone turnover via prostaglandin E2 (PGE2). Diets high in n-3 fatty acids reduced PGE2. Thus the objective was to compare the effect of diets high in n-6 and n-3 fatty acids on hyperparathyroidism, bone turnover, and PGE2 in
Improved growth in growth retarded uremic rats with use of calorie supplementation.
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Renal failure in childhood is often associated with poor growth. Growth in uremia was studied using young growing male Sprague-Dawley rats made moderately uremic (SUN77 mg/100 ml) by partial nephrectomy. Uremic rats weighed less than control rats after 17 days of observation (P less than .01).
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