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urinary bladder neoplasms/protease
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Further studies on the effect of leupeptin, a protease inhibitor, on induction of bladder tumors in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
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The effect of a microbial protease inhibitor, leupeptin, on the induction of urinary bladder tumors in W rats by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was examined. Three groups of animals were given 0.01% BBN in their drinking water for 12 weeks. A basal powder diet supplemented with 0.1%
Effect of leupeptin, a protease inhibitor, on induction of bladder tumors in rats by n-butyl-n-(4-hydroxybutyl)nitrosamine.
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Leupeptin, isolated from Actinomycetes, is a potent and specific inhibitor of proteases. We found that the administration of leupeptin enhanced that size of urinary bladder tumors induced in rats by the oral administration of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). BBN was given as a 0.05%
[Immunohistochemical characteristics and a degree of differentiation of urinary bladder cancer].
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17 cases of severe dysplasia and urinary bladder intraepithelial carcinoma, 15 cases of invasive well differentiated urothelial carcinoma, 14 cases of moderately differentiated and 10 cases of poorly differentiated carcinoma were studied immunohistochemically. The role of metalloproteinases in
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer.
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BACKGROUND
Ovarian cancer (OVC) is the deadliest of all gynecologic cancers, primarily as a consequence of asymptomatic progression. The complex nature of OVC creates challenges for early detection, and there is a lack of specific and sensitive biomarkers suitable for screening and detecting early
Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice.
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Epidemiologic data suggest that soy consumption may protect against cancer induction in several tissues in humans. Although the soy components responsible for this activity remain unidentified, isoflavones (e.g., genistein) and protease inhibitors (e.g., Bowman-Birk inhibitor complex [BBIC])
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