MPFF [Detralex®, Servier, France] 1,000 mg OD for 30 days in the postoperative period.

No venoactive drug prescribed in the postoperative period.

Varicose Veins

Surgery

Based on the (non-)use of adjuvant phlebotropic therapy in the postoperative period.

Micronized Purified Flavonoid Fraction

Educational Institution "Belarusian State Medical University"

MIcronized Flavonoid Fraction After MechanO-Chemical Ablation

Efficacy of MIcronized Purified Flavonoid Fraction-Based Phlebotropic Therapy After Endovenous MechanO-Chemical Ablation

None (0), Occasional (1), Daily, interfering with, but not preventing regular daily activities (2), Daily, limiting most regular daily activities (3)

None (0), Limited to foot or ankle (1), Extends above ankle but below knee (2), Extends to knee or above (3)

None (0), Limited to paramalleolar area (1), Diffuse over lower third of calf (2), Wider distribution (above lower third of calf) (3)

Responders; elimination of reflux through the saphenofemoral/saphenopopliteal junctions and/or coplete occlusion of the great/small saphenous veins at 8 weeks, as measured by duplex ultrasound.

To evaluate clinical efficacy of micronized purified flavonoid fraction (MPFF) phlebotropic therapy for postoperative pain, venospecific symptoms, and quality of life in patients with varicose veins (VV) following an endovenous mechanochemical ablation procedure (MOCA).

Vladimir Khryshchanovich

Professor

Belarusian State Medical University

For pregnant women randomized to the no stocking use group, no compression stockings will be worn.

Patients who are randomized to the stocking use group (Treatment Subgroup A) will be formally measured for their stockings by a certified stocking fitter, given (at no charge) two pair of 20-30mmg Hg maternity pantyhose compression stockings, and will undergo a brief tutorial regarding how to put the stockings on. Each patient will be instructed to wear the stockings on a daily basis, during the day.

Venous Insufficiency

20-30mmg Hg maternity pantyhose compression stockings

Compression Stockings

Johns Hopkins Bayview Medical Center and Johns Hopkins Hospital

Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings

Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings: A Randomized Pilot Study

In pregnant women who do not have varicose veins (Group 1): To quantify and compare the incidence of varicose veins between participants randomized to the compression stocking use group (Group 1A) and those randomized to the no compression stocking use group (Group 1B).

In pregnant women who already have varicose veins (Group 2): To quantify and compare the incidence of superficial thrombophlebitis and DVT between those randomized to the compression stocking use group (Group 2A) and those randomized to the no compression stocking use group (Group 2B).

For All Groups: To quantify and compare the incidence of symptoms of venous insufficiency in pregnant women between the treatment and control groups.

Johns Hopkins University

Sigvaris Corporation

VNUS® RF ClosureFAST is a minimally invasive varicose vein treatment procedure that uses radiofrequency energy (electricity) to heat, collapse and seal off the targeted blood vessels.

VNUS RF ClosureFAST

Endovenous Laser Treatment (EVLT) uses laser energy, which is a highly concentrated beam of light to treat varicose veins.

VenaCure EVLT NeverTouch

UC Davis Interventional and Vascular Radiology

Batey Cardiovascular and Vein Center

Midwest Institute for Minimally Invasive Therapies (MIMIT)

Novi Vein Center

NYU Langone Medical Center

University of Rochester Medical Center

Comparison Study for Safety and Efficacy of Two Devices for the Treatment of the Great Saphenous Vein

A Multi-Center, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Subjects Comparing the NeverTouch Versus the RF ClosureFAST Methods of Treatment of the Great Saphenous Vein

The VAS scale for pain will be used through the 30 day follow up time period. The questionnaires for quality of life will be used for each of the visits including the 6 and 12 month follow up visits.

A blinded healthcare professional (selected by the PI at each site) will evaluate the subject at the designated timepoints.

varicose veins/fatigue

MIcronized Flavonoid Fraction After MechanO-Chemical Ablation

Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings

Comparison Study for Safety and Efficacy of Two Devices for the Treatment of the Great Saphenous Vein

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