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z ligustilide/ligusticum porteri
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Antinociceptive activity of Ligusticum porteri preparations and compounds.
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BACKGROUND
The roots and rhizomes of Ligusticum porteri Coulter & Rose (Apiaceae) are widely used in Mexican folk medicine for several purposes, including painful complaints.
OBJECTIVE
The main goal of this work was to demonstrate the analgesic action in mice of some preparations and major compounds
Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives.
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The chemical constituents of the organic extracts from the rhizomes of Ligusticum porteri were isolated, characterised and identified as Z-ligustilide, Z-butylidenephthalide, diligustilide, tokinolide B, riligustilide, senkyunolides F and I, ferulic acid, among other known compounds. The preparation
(Z)-3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.
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An extract from the roots of Ligusticum porteri, orally administered to groups of normal and diabetic mice, showed significant hypoglycemic and antihyperglycemic effects. Experimental type-II DM was achieved by treating mice with streptozotocin 15 min after an injection of β-nicotinamide adenine
Quantitative HPLC method for determining two of the major active phthalides from Ligusticum porteri roots.
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Z-Ligustilide (1) and Z-6,6',7,3'-alpha-diligustilide (2), two of the major active phthalides of the medicinal plant Ligusticum porteri (osha), were chosen for the development and validation of an HPLC-diode array detection method suitable for QC of the crude drug. The method used gradient elution
Phthalides: Distribution in Nature, Chemical Reactivity, Synthesis, and Biological Activity.
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Phthalides are a relatively small group of natural compounds confined to several plant families and some genera of fungi and liverworts. They are divided into two structural groups, the monomeric and dimeric phthalides, and known mainly as bioactive constituents of different plant species used
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