Prevalence of Thyroid Function Abnormalities in HIV-infected Patients
Lykilorð
Útdráttur
Lýsing
Since the appearance of high-efficiency anti-retrovirals (HAARTs) in the treatment of Human Immunodeficiency Virus (HIV), several studies have shown an increase in the prevalence of hypothyroidism (frank, rough or low hypothyroidism T4) in cohorts of HIV-infected adults and children. More specifically, rough hypothyroidism (increased TSH and normal thyroid peripheral hormones) have a prevalence of about 3-12% in HIV-treated patients, which is higher than the general population of about 4.3%. The etiology of frustrated hypothyroidism remains debated in the literature; Effects of antiretroviral therapy (ARV) such as Stavudine®, the effect of dyslipidemia, the effect of HIV infection itself, in proportion to severity (expressed as low CD4 cell count) and AIDS stage. Thyroid dysfunction does not appear to be of autoimmune origin, as anti-peroxidase antibodies are rarely present in HIV-infected patients, unlike the general population.
With the increased life expectancy of HIV-infected patients and the indications of different experts to be treated earlier, the duration of exposure to ARVs is also increasing. Therefore, their chronic toxicity deserves particular attention, in particular on thyroid function and / or thyroid hormone metabolism, since iatrogenicity has not been completely ruled out. In addition, clinical evidence suggests that dysthyroids may be corrected or worsened over time in HIV patients (unpublished personal data).
Today, the natural history of frustrated hypothyroidism and its consequences are not reported in patients infected with HIV. However, it is recognized in the elderly, fructified hypothyroidism evolves over time towards frank hypothyroidism; The latter is associated with an increased prevalence of dyslipidemia, atherosclerosis, diastolic hypertension and therefore an increased risk of myocardial infarction.
It therefore seems interesting to review the evolution of thyroid function in HIV-infected patients, with sufficient follow-up.
Dagsetningar
| Síðast staðfest: | 07/31/2018 |
| Fyrst lagt fram: | 05/03/2017 |
| Áætluð skráning lögð fram: | 05/08/2017 |
| Fyrst sent: | 05/10/2017 |
| Síðasta uppfærsla lögð fram: | 08/02/2018 |
| Síðasta uppfærsla sett upp: | 08/06/2018 |
| Raunverulegur upphafsdagur náms: | 12/18/2012 |
| Áætlaður aðallokunardagur: | 12/18/2022 |
| Áætlaður dagsetningu rannsóknar: | 12/18/2022 |
Ástand eða sjúkdómur
Íhlutun / meðferð
Other: Patients with HIV
Stig
Armhópar
| Armur | Íhlutun / meðferð |
|---|---|
| Other: Patients with HIV Patients with HIV | Other: Patients with HIV Assay of TSH, FT3 and FT4 by immuno-radiometric method Determine the current prevalence of hypothyroidism in HIV-infected patients |
Hæfniskröfur
| Aldur hæfur til náms | 18 Years Til 18 Years |
| Kyn sem eru hæf til náms | All |
| Tekur við heilbrigðum sjálfboðaliðum | Já |
| Viðmið | Inclusion Criteria: - Major Patients. - Infected with HIV, regardless of stage of disease and treatment, diagnosed between January 2001 and December 2012 - Follow-up at the University Hospital of Amiens. Exclusion Criteria: - Patients in the THIVY1 study lost to follow-up since 2001, having moved or undergoing therapeutic break-up - Deceased Patients - Major protected persons (under guardianship or guardianship) - Pregnant women - Refusal of participation |
Útkoma
Aðal niðurstöður ráðstafanir
1. Determine the current prevalence of hypothyroidism [10 years]
Heillasta gagnagrunnur lækningajurtanna sem studdur er af vísindum
- Virkar á 55 tungumálum
- Jurtalækningar studdir af vísindum
- Jurtaviðurkenning eftir ímynd
- Gagnvirkt GPS kort - merktu jurtir á staðsetningu (kemur fljótlega)
- Lestu vísindarit sem tengjast leit þinni
- Leitaðu að lækningajurtum eftir áhrifum þeirra
- Skipuleggðu áhugamál þitt og vertu vakandi með fréttarannsóknum, klínískum rannsóknum og einkaleyfum
Sláðu inn einkenni eða sjúkdóm og lestu um jurtir sem gætu hjálpað, sláðu jurt og sjáðu sjúkdóma og einkenni sem hún er notuð við.
* Allar upplýsingar eru byggðar á birtum vísindarannsóknum
