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Journal of biomedicine & biotechnology 2012

Antiproliferative activity of xanthones isolated from Artocarpus obtusus.

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Krækjan er vistuð á klemmuspjaldið
Najihah Mohd Hashim
Mawardi Rahmani
Gwendoline Cheng Lian Ee
Mohd Aspollah Sukari
Maizatulakmal Yahayu
Winda Oktima
Abd Manaf Ali
Rusea Go

Lykilorð

Útdráttur

An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC(50) values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC(50) values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC(50) values of more than 30 μg/mL.

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