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Involvement of IL-10, an anti-inflammatory cytokine in murine liver injury induced by Concanavalin A.

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A mechanism of liver injury such as, viral hepatitis or autoimmune hepatitis is considered to involve the impairment of hepatocytes mainly mediated by T-cell immunity, but the roles of a variety of cytokines involved in regulation remain unclarified. We investigated the involvement of various

Systemic inflammation after aortic cross clamping is influenced by Toll-like receptor 2 preconditioning and deficiency.

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BACKGROUND The perioperative morbidity and mortality of abdominal aortic aneurysm repair is linked to systemic inflammation. Important triggers of the latter are Toll-like receptors (TLRs), which play a central role in innate immunity. Ischemia/reperfusion (I/R) injury can be influenced by either

[A case of hepatitis B virus/human immunodeficiency virus coinfection in a patient who achived hepatitis B surface antigen seroclearance after interferon therapy followed by antiretroviral therapy without developing immune reconstitution inflammatory syndrome].

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Coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) is common worldwide. The current guidelines for the treatment of HIV infection recommend that HIV patients coinfected with HBV receive antiretoroviral therapy (ART) with two nucleoside analogs against HBV. However, an

Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass.

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High mobility group box 1 (HMGB1), which is released by activated immune cells and necrotic cells, has properties similar to those of pro-inflammatory cytokines. Cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted

Mycobacterium tuberculosis PPE18 Protein Reduces Inflammation and Increases Survival in Animal Model of Sepsis.

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Mycobacterium tuberculosis PPE18 is a member of the PPE family. Previous studies have shown that recombinant PPE18 (rPPE18) protein binds to TLR2 and triggers a signaling cascade which reduces levels of TNF-α and IL-12, and increases IL-10 in macrophages. Because TNF-α is a major mediator of the

LBP inhibitory peptide reduces endotoxin-induced macrophage activation and mortality.

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OBJECTIVE The aim of this study was to investigate whether P12, a lipopolysaccharide (LPS)-binding protein (LBP) inhibitory peptide could reduce LPS induced inflammation in vitro and in vivo. METHODS Human monocyte-like cell line (U937 cells) was grown in RPMI 1640 and stimulated with PMA in order

[Effects of PNU282987 on organ function and survival in dogs with lethal burn shock].

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OBJECTIVE To investigate the effects of PNU282987, a α7 nicotinic acetylcholine receptor agonist (α7nAChR), on organ function and survival rate in dogs with lethal burn shock. METHODS Twelve adult male Beagle dogs were subjected to 50% total body surface area (TBSA) full-thickness flame injury, and

Exercises in hot and humid environment caused liver injury in a rat model.

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OBJECTIVE To investigate injury pattern during intense exercises in hot and humid environment particularly on liver in a rat exertional heat stroke model. METHODS We randomly divided 30 rats into a control group (CG), a normal temperature (25±2°C, 60%±5% humidity) exercise group (NTEG) and a high

Liver-lung interactions following Escherichia coli bacteremic sepsis and secondary hepatic ischemia/reperfusion injury.

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We hypothesized that ischemia/reperfusion (I/R) injury of the liver during normotensive gram-negative bacteremic sepsis alters the kinetics of circulating endotoxin, tumor necrosis factor-alpha (TNF-alpha), and coinduced mediators, thereby exacerbating sepsis-induced lung inflammation. Liver and

Swim exercise training ameliorates hepatocyte ultrastructural alterations in rats fed on a high fat and sugar diet.

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Excessive consumption of carbohydrate and fat increases the risk of liver disease. We hypothesized that swim exercise can protect hepatocytes from ultra-structural damage induced by high cholesterol and fructose diets (HCFD). Rats were either fed with HCFD (model group) or a standard laboratory chow

The effect of interferon alfa and ribavirin combination therapy in naive patients with chronic hepatitis C.

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BACKGROUND Chronic hepatitis C may lead to cirrhosis and hepatocellular carcinoma in a subset of patients. Because response rates with interferon alfa therapy are unsatisfactory, new therapies are needed. METHODS We conducted a three-arm, randomized trial in 45 interferon-naive men (mean age 40.6

Shenfu Injection Attenuates Bile Duct Injury in Rats with Acute Obstructive Cholangitis.

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Background: We investigated the effect of Shenfu injection (SFI) in Wistar rats with acute obstructive cholangitis (AOC) and considered the possible molecular mechanisms of the effects. Methods: The 96 rats were divided randomly into three groups. In one group, the common bile duct was

Efficacy of synbiotic supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials: Synbiotic supplementation and NAFLD.

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OBJECTIVE We systematically reviewed available randomized clinical trials (RCTs) to elucidate the overall effects of synbiotic supplementation in patients with nonalcoholic fatty liver disease (NAFLD). METHODS PubMed, Scopus, ISI Web of science and Google Scholar were searched up to December, 2017.

High-resolution 1H NMR spectroscopy of cerebrospinal fluid in spinal diseases.

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Twenty-nine patients with disk herniations, 7 patients with intraspinal tumors, 4 patients with multiple sclerosis and one patient with infection by borrelia have been studied by CT, myelography and/or MR. To gain information on the metabolism of central nervous system disease (CNS), and thus, to

Cross-sectional association between sugar-sweetened beverage intake and cardiometabolic biomarkers in US women.

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Few studies have evaluated the relationships between intake of sugar-sweetened beverages (SSB) and intermediate biomarkers of cardiometabolic risk. Associations between artificially sweetened beverages (ASB) and fruit juice with cardiometabolic biomarkers are also unclear. We investigated habitual

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